Stepwise Unfolding of a β Barrel Protein by the AAA+ ClpXP Protease
In the AAA+ ClpXP protease, ClpX uses the energy of ATP binding and hydrolysis to unfold proteins before translocating them into ClpP for degradation. For proteins with C-terminal ssrA tags, ClpXP pulls on the tag to initiate unfolding and subsequent degradation. Here, we demonstrate that an initial...
Main Authors: | Nager, Andrew Ross (Contributor), Sauer, Robert T. (Contributor), Baker, Tania (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2015-10-06T19:23:34Z.
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Subjects: | |
Online Access: | Get fulltext |
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