An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides

A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent....

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Bibliographic Details
Main Authors: Fors, Brett P. (Contributor), Dooleweerdt, Karin (Contributor), Zeng, Qingle (Contributor), Buchwald, Stephen Leffler (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-28T12:51:22Z.
Subjects:
Online Access:Get fulltext
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042 |a dc 
100 1 0 |a Fors, Brett P.  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
100 1 0 |a Fors, Brett P.  |e contributor 
100 1 0 |a Dooleweerdt, Karin  |e contributor 
100 1 0 |a Zeng, Qingle  |e contributor 
100 1 0 |a Buchwald, Stephen Leffler  |e contributor 
700 1 0 |a Dooleweerdt, Karin  |e author 
700 1 0 |a Zeng, Qingle  |e author 
700 1 0 |a Buchwald, Stephen Leffler  |e author 
245 0 0 |a An efficient system for the Pd-catalyzed cross-coupling of amides and aryl chlorides 
260 |b Elsevier,   |c 2015-10-28T12:51:22Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/99484 
520 |a A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields. 
520 |a National Institutes of Health (U.S.) (Grant GM-58160) 
520 |a Merck & Co., Inc. 
520 |a BASF 
520 |a Chemetall 
520 |a Nippon Chemical Industrial Co. 
520 |a William Asbornsen Albert Memorial Fund (Fellowship) 
520 |a University of Aarhus. Department of Chemistry 
520 |a University of Aarhus. Interdisciplinary Nanoscience Centre 
520 |a China Scholarship Council 
520 |a National Natural Science Foundation (China) (Grant 20672088) 
546 |a en_US 
655 7 |a Article 
773 |t Tetrahedron