Strategic use of nickel(0)-catalyzed enyne-epoxide reductive coupling toward the synthesis of (−)-cyatha-3,12-diene

Various situations are explored in which the nickel(0)-catalyzed enyne-epoxide reductive coupling was utilized to access key intermediates toward the total synthesis of (−)-cyatha-3,12-diene (1). Enantioenriched 3,5-dien-1-ols with a variety of functionality were obtained in a straightforward manner...

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Bibliographic Details
Main Authors: Sparling, Brian A. (Contributor), Simpson, Graham L. (Contributor), Jamison, Timothy F. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-29T17:49:40Z.
Subjects:
Online Access:Get fulltext
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100 1 0 |a Sparling, Brian A.  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
100 1 0 |a Sparling, Brian A.  |e contributor 
100 1 0 |a Simpson, Graham L.  |e contributor 
100 1 0 |a Jamison, Timothy F.  |e contributor 
700 1 0 |a Simpson, Graham L.  |e author 
700 1 0 |a Jamison, Timothy F.  |e author 
245 0 0 |a Strategic use of nickel(0)-catalyzed enyne-epoxide reductive coupling toward the synthesis of (−)-cyatha-3,12-diene 
260 |b Elsevier,   |c 2015-10-29T17:49:40Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/99513 
520 |a Various situations are explored in which the nickel(0)-catalyzed enyne-epoxide reductive coupling was utilized to access key intermediates toward the total synthesis of (−)-cyatha-3,12-diene (1). Enantioenriched 3,5-dien-1-ols with a variety of functionality were obtained in a straightforward manner from easily accessible 1,3-enynes and terminal epoxides. 
520 |a National Institute of General Medical Sciences (U.S.) (GM-063755) 
520 |a Massachusetts Institute of Technology. Undergraduate Research Opportunities Program 
546 |a en_US 
655 7 |a Article 
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