Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets

Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets

Human influenza viruses predominantly bind α2,6 linked sialic acid (SA) while avian viruses bind α2,3 SA-containing complex glycans. Virulence and tissue tropism of influenza viruses have been ascribed to this binding preference. We generated 2009 pandemic H1N1 (pH1N1) viruses with either predominan...

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Bibliographic Details
Main Authors: Lakdawala, Seema S. (Author), Shih, Angela R. (Author), Jayaraman, Akila (Contributor), Lamirande, Elaine W. (Author), Moore, Ian (Author), Paskel, Myeisha (Author), Sasisekharan, Ram (Contributor), Subbarao, Kanta (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-29T18:26:49Z.
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