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99658 |
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|a dc
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|a Niljianskul, Nootaree
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Niljianskul, Nootaree
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|a Zhu, Shaolin
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|a Buchwald, Stephen Leffler
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|a Zhu, Shaolin
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|a Buchwald, Stephen Leffler
|e author
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|a Enantioselective Synthesis of α-Aminosilanes by Copper-Catalyzed Hydroamination of Vinylsilanes
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|b Wiley Blackwell,
|c 2015-11-02T19:07:55Z.
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| 856 |
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|z Get fulltext
|u http://hdl.handle.net/1721.1/99658
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|a The synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric reductant, and O-benzoylhydroxylamines as the electrophilic nitrogen source. This hydroamination reaction is compatible with differentially substituted vinylsilanes, thus providing access to amino acid mimics and other valuable chiral organosilicon compounds.
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|a National Institutes of Health (U.S.) (Award GM58160)
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|a en_US
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|a Article
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|t Angewandte Chemie International Edition
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