3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method
Yes === Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of person...
Main Authors: | , , , , , , , |
---|---|
Language: | en |
Published: |
2019
|
Subjects: | |
Online Access: | http://hdl.handle.net/10454/17370 |
id |
ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-17370 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-173702020-07-15T07:09:31Z 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method Robles-Martinez, P. Xu, X. Trenfield, S.J. Awad, A. Goyanes, A. Telford, Richard Basit, A.W. Gaisford, S. Three-dimensional printing 3D printing Fixed-dose combinations Additive manufacturing 3D printed drug products Printlets Tablets Personalized medicines Multiple-layer dosage forms Stereolithography Vat polymerisation Yes Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, cffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with dfferent geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills. 2019-10-15T13:41:27Z 2019-10-28T14:39:28Z 2019-10-15T13:41:27Z 2019-10-28T14:39:28Z 2019-06 2019-06-03 2019-06-11 2019-10-15T12:41:40Z Article Published version Robles-Martinez P, Xu X, Trenfield SJ et al (2019) 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method. Pharmaceutics. 11(6): 274. http://hdl.handle.net/10454/17370 en https://doi.org/10.3390/pharmaceutics11060274 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
collection |
NDLTD |
language |
en |
sources |
NDLTD |
topic |
Three-dimensional printing 3D printing Fixed-dose combinations Additive manufacturing 3D printed drug products Printlets Tablets Personalized medicines Multiple-layer dosage forms Stereolithography Vat polymerisation |
spellingShingle |
Three-dimensional printing 3D printing Fixed-dose combinations Additive manufacturing 3D printed drug products Printlets Tablets Personalized medicines Multiple-layer dosage forms Stereolithography Vat polymerisation Robles-Martinez, P. Xu, X. Trenfield, S.J. Awad, A. Goyanes, A. Telford, Richard Basit, A.W. Gaisford, S. 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method |
description |
Yes === Three-dimensional printing (3DP) has demonstrated great potential for multi-material
fabrication because of its capability for printing bespoke and spatially separated material
conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the
production of personalised, multi-layered drug products on demand. Here, we developed a novel
stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer
constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs,
including paracetamol, cffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed
with dfferent geometries and material compositions. Drug distribution was visualised using Raman
microscopy, which showed that whilst separate layers were successfully printed, several of the drugs
diffused across the layers depending on their amorphous or crystalline phase. The printed constructs
demonstrated excellent physical properties and the different material inclusions enabled distinct drug
release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the
feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a
new era of personalised polypills. |
author |
Robles-Martinez, P. Xu, X. Trenfield, S.J. Awad, A. Goyanes, A. Telford, Richard Basit, A.W. Gaisford, S. |
author_facet |
Robles-Martinez, P. Xu, X. Trenfield, S.J. Awad, A. Goyanes, A. Telford, Richard Basit, A.W. Gaisford, S. |
author_sort |
Robles-Martinez, P. |
title |
3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method |
title_short |
3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method |
title_full |
3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method |
title_fullStr |
3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method |
title_full_unstemmed |
3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method |
title_sort |
3d printing of a multi-layered polypill containing six drugs using a novel stereolithographic method |
publishDate |
2019 |
url |
http://hdl.handle.net/10454/17370 |
work_keys_str_mv |
AT roblesmartinezp 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod AT xux 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod AT trenfieldsj 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod AT awada 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod AT goyanesa 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod AT telfordrichard 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod AT basitaw 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod AT gaisfords 3dprintingofamultilayeredpolypillcontainingsixdrugsusinganovelstereolithographicmethod |
_version_ |
1719325423134834688 |