Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets
yes === Cardiovascular diseases (CVDs) are the leading cause of death globally. While the major focus of pharmacological and non-pharmacological interventions has been on targeting disease pathophysiology and limiting predisposing factors, our understanding of the cellular and molecular mechanisms u...
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ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-184802021-05-21T05:00:54Z Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets Bolanle, I.O. Riches-Suman, Kirsten Williamson, Ritchie Palmer, Timothy M. Cardiovascular disease Protein O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase yes Cardiovascular diseases (CVDs) are the leading cause of death globally. While the major focus of pharmacological and non-pharmacological interventions has been on targeting disease pathophysiology and limiting predisposing factors, our understanding of the cellular and molecular mechanisms underlying the pathogenesis of CVDs remains incomplete. One mechanism that has recently emerged is protein O-GlcNAcylation. This is a dynamic, site-specific reversible post-translational modification of serine and threonine residues on target proteins and is controlled by two enzymes: O-linked β-N-acetylglucosamine transferase (OGT) and O-linked β-N-acetylglucosaminidase (OGA). Protein O-GlcNAcylation alters the cellular functions of these target proteins which play vital roles in pathways that modulate vascular homeostasis and cardiac function. Through this review, we aim to give insights on the role of protein O-GlcNAcylation in cardiovascular diseases and identify potential therapeutic targets in this pathway for development of more effective medicines to improve patient outcomes. The full text will be available at the end of the publisher's embargo: 27th Jan 2022 2021-05-05T15:12:45Z 2021-05-19T15:35:57Z 2021-05-05T15:12:45Z 2021-05-19T15:35:57Z 2021-03 2022-01-27 2021-05-05T14:12:47Z Article Accepted manuscript Bolanle IO, Riches-Suman K, Williamson R, Palmer TM (2021) Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets. Pharmacological Research. 165: 105467 http://hdl.handle.net/10454/18480 en https://doi.org/10.1016/j.phrs.2021.105467 © 2021 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. |
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Cardiovascular disease Protein O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase |
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Cardiovascular disease Protein O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase Bolanle, I.O. Riches-Suman, Kirsten Williamson, Ritchie Palmer, Timothy M. Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets |
description |
yes === Cardiovascular diseases (CVDs) are the leading cause of death globally. While the major focus of pharmacological and non-pharmacological interventions has been on targeting disease pathophysiology and limiting predisposing factors, our understanding of the cellular and molecular mechanisms underlying the pathogenesis of CVDs remains incomplete. One mechanism that has recently emerged is protein O-GlcNAcylation. This is a dynamic, site-specific reversible post-translational modification of serine and threonine residues on target proteins and is controlled by two enzymes: O-linked β-N-acetylglucosamine transferase (OGT) and O-linked β-N-acetylglucosaminidase (OGA). Protein O-GlcNAcylation alters the cellular functions of these target proteins which play vital roles in pathways that modulate vascular homeostasis and cardiac function. Through this review, we aim to give insights on the role of protein O-GlcNAcylation in cardiovascular diseases and identify potential therapeutic targets in this pathway for development of more effective medicines to improve patient outcomes. === The full text will be available at the end of the publisher's embargo: 27th Jan 2022 |
author |
Bolanle, I.O. Riches-Suman, Kirsten Williamson, Ritchie Palmer, Timothy M. |
author_facet |
Bolanle, I.O. Riches-Suman, Kirsten Williamson, Ritchie Palmer, Timothy M. |
author_sort |
Bolanle, I.O. |
title |
Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets |
title_short |
Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets |
title_full |
Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets |
title_fullStr |
Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets |
title_full_unstemmed |
Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets |
title_sort |
emerging roles of protein o-glcnacylation in cardiovascular diseases: insights and novel therapeutic targets |
publishDate |
2021 |
url |
http://hdl.handle.net/10454/18480 |
work_keys_str_mv |
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