Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials
Yes === Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as well as research. The accurate spatial characterization of visual function enabled by FCP...
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ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-186272021-10-22T05:01:04Z Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials Pfau, M. Jolly, J.K. Wu, Z. Denniss, Jonathan Lad, E.M. Guymer, R.H. Fleckenstein, M. Holz, F.G. Schmitz-Valckenberg, S. Retina Microperimetry FCP Age-related macular degeneration Inherited retinal diseases Inherited retinal dystrophy Functional outcome measures Yes Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as well as research. The accurate spatial characterization of visual function enabled by FCP can provide insightful information about disease severity and progression not reflected by best-corrected visual acuity in a large range of disorders. This is especially important for monitoring of retinal diseases that initially spare the central retina in earlier disease stages. Improved intra- and inter-session retest-variability through fundus-tracking and precise point-wise follow-up examinations even in patients with unstable fixation represent key advantages of these technique. The design of disease-specific test patterns and protocols reduces the burden of extensive and time-consuming FCP testing, permitting a more meaningful and focused application. Recent developments also allow for photoreceptor-specific testing through implementation of dark-adapted chromatic and photopic testing. A detailed understanding of the variety of available devices and test settings is a key prerequisite for the design and optimization of FCP protocols in future natural history studies and clinical trials. Accordingly, this review describes the theoretical and technical background of FCP, its prior application in clinical and research settings, data that qualify the application of FCP as an outcome measure in clinical trials as well as ongoing and future developments. 2021-10-11T07:42:57Z 2021-10-20T07:58:28Z 2021-10-11T07:42:57Z 2021-10-20T07:58:28Z 2021-05 2020-09-23 2020-10-03 2021-10-11T07:43:02Z Article Published version Pfau M, Jolly JK, Wu Z et al (2021) Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials. Progress in Retinal and Eye Research. 82: 100907. http://hdl.handle.net/10454/18627 en https://doi.org/10.1016/j.preteyeres.2020.100907 (c) 2021 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
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en |
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Retina Microperimetry FCP Age-related macular degeneration Inherited retinal diseases Inherited retinal dystrophy Functional outcome measures |
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Retina Microperimetry FCP Age-related macular degeneration Inherited retinal diseases Inherited retinal dystrophy Functional outcome measures Pfau, M. Jolly, J.K. Wu, Z. Denniss, Jonathan Lad, E.M. Guymer, R.H. Fleckenstein, M. Holz, F.G. Schmitz-Valckenberg, S. Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials |
description |
Yes === Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as well as research. The accurate spatial characterization of visual function enabled by FCP can provide insightful information about disease severity and progression not reflected by best-corrected visual acuity in a large range of disorders. This is especially important for monitoring of retinal diseases that initially spare the central retina in earlier disease stages. Improved intra- and inter-session retest-variability through fundus-tracking and precise point-wise follow-up examinations even in patients with unstable fixation represent key advantages of these technique. The design of disease-specific test patterns and protocols reduces the burden of extensive and time-consuming FCP testing, permitting a more meaningful and focused application. Recent developments also allow for photoreceptor-specific testing through implementation of dark-adapted chromatic and photopic testing. A detailed understanding of the variety of available devices and test settings is a key prerequisite for the design and optimization of FCP protocols in future natural history studies and clinical trials. Accordingly, this review describes the theoretical and technical background of FCP, its prior application in clinical and research settings, data that qualify the application of FCP as an outcome measure in clinical trials as well as ongoing and future developments. |
author |
Pfau, M. Jolly, J.K. Wu, Z. Denniss, Jonathan Lad, E.M. Guymer, R.H. Fleckenstein, M. Holz, F.G. Schmitz-Valckenberg, S. |
author_facet |
Pfau, M. Jolly, J.K. Wu, Z. Denniss, Jonathan Lad, E.M. Guymer, R.H. Fleckenstein, M. Holz, F.G. Schmitz-Valckenberg, S. |
author_sort |
Pfau, M. |
title |
Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials |
title_short |
Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials |
title_full |
Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials |
title_fullStr |
Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials |
title_full_unstemmed |
Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials |
title_sort |
fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials |
publishDate |
2021 |
url |
http://hdl.handle.net/10454/18627 |
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