Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances
No === Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invalu...
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ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-33382019-08-31T03:02:12Z Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances Anwar, Jamshed Noro, M.G. Notman, R. O'Malley, B. Dimethylsulfoxide DMSO Lipid membranes No Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invaluable toward regulating the above processes and for developing chemical means for enhancing or hindering the absorption of biologically active molecules, in particular into or via the skin. We show here by means of molecular simulations that DMSO can induce water pores in dipalmitoyl-phosphatidylcholine bilayers and propose this to be a possible pathway for the enhancement of penetration of actives through lipid membranes. DMSO also causes the membrane to become floppier, which would enhance permeability, facilitate membrane fusion, and enable the cell membrane to accommodate osmotic and mechanical stresses during cryopreservation. 2009-08-19T09:36:05Z 2009-08-19T09:36:05Z 2006 Article No full-text available in the repository Notman, R., Noro, M.G., O'Malley, B. and Anwar, J. (2006). Journal of American Chemical Society. Vol. 128, No. 43, pp. 13982-3. http://hdl.handle.net/10454/3338 en http://dx.doi.org/10.1021/ja063363t |
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en |
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Dimethylsulfoxide DMSO Lipid membranes |
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Dimethylsulfoxide DMSO Lipid membranes Anwar, Jamshed Noro, M.G. Notman, R. O'Malley, B. Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances |
description |
No === Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invaluable toward regulating the above processes and for developing chemical means for enhancing or hindering the absorption of biologically active molecules, in particular into or via the skin. We show here by means of molecular simulations that DMSO can induce water pores in dipalmitoyl-phosphatidylcholine bilayers and propose this to be a possible pathway for the enhancement of penetration of actives through lipid membranes. DMSO also causes the membrane to become floppier, which would enhance permeability, facilitate membrane fusion, and enable the cell membrane to accommodate osmotic and mechanical stresses during cryopreservation. |
author |
Anwar, Jamshed Noro, M.G. Notman, R. O'Malley, B. |
author_facet |
Anwar, Jamshed Noro, M.G. Notman, R. O'Malley, B. |
author_sort |
Anwar, Jamshed |
title |
Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances |
title_short |
Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances |
title_full |
Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances |
title_fullStr |
Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances |
title_full_unstemmed |
Molecular basis for dimethylsulfoxide (DMSO) Action on Lipid Membrances |
title_sort |
molecular basis for dimethylsulfoxide (dmso) action on lipid membrances |
publishDate |
2009 |
url |
http://hdl.handle.net/10454/3338 |
work_keys_str_mv |
AT anwarjamshed molecularbasisfordimethylsulfoxidedmsoactiononlipidmembrances AT noromg molecularbasisfordimethylsulfoxidedmsoactiononlipidmembrances AT notmanr molecularbasisfordimethylsulfoxidedmsoactiononlipidmembrances AT omalleyb molecularbasisfordimethylsulfoxidedmsoactiononlipidmembrances |
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1719239507404914688 |