beta-Endorphin as a regulator of human hair follicle melanocyte biology.
No === The pro-opiomelanocortin (POMC)-derived peptides, -melanocyte-stimulating hormone, and adrenocorticotropic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 receptor. Recent data suggests that such a regulatory role also exists for the endogenous opi...
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ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-36062019-08-31T03:02:12Z beta-Endorphin as a regulator of human hair follicle melanocyte biology. Kauser, Sobia Thody, Anthony J. Schallreuter, Karin U. Tobin, Desmond J. Gummer, C.L. Dendricity Hair pigmentation, Melanogenesis Opiate receptor No The pro-opiomelanocortin (POMC)-derived peptides, -melanocyte-stimulating hormone, and adrenocorticotropic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 receptor. Recent data suggests that such a regulatory role also exists for the endogenous opiate, -endorphin (-END). A role for this -END in the regulation of follicular pigmentation, however, has not been determined. This study was designed to examine the involvement of the -END/-opiate receptor system in human follicular melanocyte biology. We employed RT-PCR, and immunohisto/cytochemistry and immunoelectron microscopy using -END and -opiate receptor specific antibodies and a functional role for -END was assessed by direct stimulation with the peptide. This study has demonstrated that human hair follicle melanocytes (HFM) express mRNA for the -opiate receptor and POMC. Furthermore, -END and its high affinity -opiate receptor are expressed at the protein level in glycoprotein100-positive follicular melanocytes and as a function of their anatomic location and differentiation status during the hair growth cycle. Functional studies revealed that -END is a modifier of HFM phenotype via its ability to upregulate melanogenesis, dendricity, and proliferation. These findings suggest a new regulatory role for -END in human HFM biology, providing a new research direction into the fundamental regulation of human hair pigmentation. 2009-10-05T13:22:30Z 2009-10-05T13:22:30Z 2004 Article No full-text available in the repository Kauser, S., Thody, A.J., Schallreuter, K.U. and Tobin, D.J. et al. (2004). beta-Endorphin as a regulator of human hair follicle melanocyte biology. Journal of Investigative Dermatology. Vol. 123, No. 1, pp. 184-195. http://hdl.handle.net/10454/3606 en http://dx.doi.org/10.1111/j.0022-202X.2004.22724.x |
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en |
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Dendricity Hair pigmentation, Melanogenesis Opiate receptor |
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Dendricity Hair pigmentation, Melanogenesis Opiate receptor Kauser, Sobia Thody, Anthony J. Schallreuter, Karin U. Tobin, Desmond J. Gummer, C.L. beta-Endorphin as a regulator of human hair follicle melanocyte biology. |
description |
No === The pro-opiomelanocortin (POMC)-derived peptides, -melanocyte-stimulating hormone, and adrenocorticotropic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 receptor. Recent data suggests that such a regulatory role also exists for the endogenous opiate, -endorphin (-END). A role for this -END in the regulation of follicular pigmentation, however, has not been determined. This study was designed to examine the involvement of the -END/-opiate receptor system in human follicular melanocyte biology. We employed RT-PCR, and immunohisto/cytochemistry and immunoelectron microscopy using -END and -opiate receptor specific antibodies and a functional role for -END was assessed by direct stimulation with the peptide. This study has demonstrated that human hair follicle melanocytes (HFM) express mRNA for the -opiate receptor and POMC. Furthermore, -END and its high affinity -opiate receptor are expressed at the protein level in glycoprotein100-positive follicular melanocytes and as a function of their anatomic location and differentiation status during the hair growth cycle. Functional studies revealed that -END is a modifier of HFM phenotype via its ability to upregulate melanogenesis, dendricity, and proliferation. These findings suggest a new regulatory role for -END in human HFM biology, providing a new research direction into the fundamental regulation of human hair pigmentation. |
author |
Kauser, Sobia Thody, Anthony J. Schallreuter, Karin U. Tobin, Desmond J. Gummer, C.L. |
author_facet |
Kauser, Sobia Thody, Anthony J. Schallreuter, Karin U. Tobin, Desmond J. Gummer, C.L. |
author_sort |
Kauser, Sobia |
title |
beta-Endorphin as a regulator of human hair follicle melanocyte biology. |
title_short |
beta-Endorphin as a regulator of human hair follicle melanocyte biology. |
title_full |
beta-Endorphin as a regulator of human hair follicle melanocyte biology. |
title_fullStr |
beta-Endorphin as a regulator of human hair follicle melanocyte biology. |
title_full_unstemmed |
beta-Endorphin as a regulator of human hair follicle melanocyte biology. |
title_sort |
beta-endorphin as a regulator of human hair follicle melanocyte biology. |
publishDate |
2009 |
url |
http://hdl.handle.net/10454/3606 |
work_keys_str_mv |
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