Ischaemic skeletal muscle increases serum ischaemia modified albumin.
No === Objectives Ischaemia modified albumin (IMA) has been used as a marker of myocardial ischaemia but little is known about its production during ischaemia of other tissues. The clinical models of patients with intermittent claudication and major arterial surgery were used to investigate IMA pro...
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ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-38052019-08-31T03:02:15Z Ischaemic skeletal muscle increases serum ischaemia modified albumin. Troxler, M. Thompson, D. Homer-Vanniasinkam, Shervanthi Skeletal Muscle Serum albumin Ischemia, No Objectives Ischaemia modified albumin (IMA) has been used as a marker of myocardial ischaemia but little is known about its production during ischaemia of other tissues. The clinical models of patients with intermittent claudication and major arterial surgery were used to investigate IMA production from ischaemic skeletal muscle. Materials and methods IMA was measured pre-operatively, at end ischaemia, and 5min, 4, 24, 48, 72 and 144h post-surgery in patients undergoing (a) revascularisation for intermittent claudication (IC, n=15), (b) abdominal aortic aneurysm repair (AAA, n=12) and controls (n=16). Results The median pre-operative IMA concentration in IC patients was significantly higher than the AAA group (88.3 versus 83.5U/ml, p=0.036) and controls (88.3 versus 80.3U/ml, p=0.031). IMA concentrations increased significantly during arterial clamping in both IC and AAA groups (88.3 versus 120.0U/ml, p=0.001; 83.5 versus 118.8U/ml, p=0.002, respectively) consistent with increased skeletal muscle ischaemia. In contrast, there was only a mild perioperative increase in the controls (80.3 versus 91.6U/ml, p=0.012). Conclusions Patients with intermittent claudication have significantly elevated IMA and skeletal muscle ischaemia during arterial surgery results in significantly increased circulating IMA. When IMA is used to detect myocardial ischaemia, ischaemic skeletal muscle must be excluded. 2009-11-02T08:27:10Z 2009-11-02T08:27:10Z 2009-11-02T08:27:10Z Article No full-text available in the repository Troxler, M., Thompson, D. and Homer-Vanniasinkam, S. (2006). Ischaemic skeletal muscle increases serum ischaemia modified albumin. European Journal of Vascular and Endovascular Surgery. Vol. 31, No. 2, pp. 164-169. http://hdl.handle.net/10454/3805 en http://dx.doi.org/10.1016/j.ejvs.2005.06.019 |
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Skeletal Muscle Serum albumin Ischemia, |
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Skeletal Muscle Serum albumin Ischemia, Troxler, M. Thompson, D. Homer-Vanniasinkam, Shervanthi Ischaemic skeletal muscle increases serum ischaemia modified albumin. |
description |
No === Objectives
Ischaemia modified albumin (IMA) has been used as a marker of myocardial ischaemia but little is known about its production during ischaemia of other tissues. The clinical models of patients with intermittent claudication and major arterial surgery were used to investigate IMA production from ischaemic skeletal muscle.
Materials and methods
IMA was measured pre-operatively, at end ischaemia, and 5min, 4, 24, 48, 72 and 144h post-surgery in patients undergoing (a) revascularisation for intermittent claudication (IC, n=15), (b) abdominal aortic aneurysm repair (AAA, n=12) and controls (n=16).
Results
The median pre-operative IMA concentration in IC patients was significantly higher than the AAA group (88.3 versus 83.5U/ml, p=0.036) and controls (88.3 versus 80.3U/ml, p=0.031). IMA concentrations increased significantly during arterial clamping in both IC and AAA groups (88.3 versus 120.0U/ml, p=0.001; 83.5 versus 118.8U/ml, p=0.002, respectively) consistent with increased skeletal muscle ischaemia. In contrast, there was only a mild perioperative increase in the controls (80.3 versus 91.6U/ml, p=0.012).
Conclusions
Patients with intermittent claudication have significantly elevated IMA and skeletal muscle ischaemia during arterial surgery results in significantly increased circulating IMA. When IMA is used to detect myocardial ischaemia, ischaemic skeletal muscle must be excluded. |
author |
Troxler, M. Thompson, D. Homer-Vanniasinkam, Shervanthi |
author_facet |
Troxler, M. Thompson, D. Homer-Vanniasinkam, Shervanthi |
author_sort |
Troxler, M. |
title |
Ischaemic skeletal muscle increases serum ischaemia modified albumin. |
title_short |
Ischaemic skeletal muscle increases serum ischaemia modified albumin. |
title_full |
Ischaemic skeletal muscle increases serum ischaemia modified albumin. |
title_fullStr |
Ischaemic skeletal muscle increases serum ischaemia modified albumin. |
title_full_unstemmed |
Ischaemic skeletal muscle increases serum ischaemia modified albumin. |
title_sort |
ischaemic skeletal muscle increases serum ischaemia modified albumin. |
publishDate |
2009 |
url |
http://hdl.handle.net/10454/3805 |
work_keys_str_mv |
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