Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts

Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts

<p>The integrity of DNA replication control and checkpoint mechanisms is essential for preventing tumorigenesis. DNA replication is initiated by the S-CDK and DDK kinases which mediate the unwinding of the replication fork. Genotoxic stress which specifically affects cells in S-phase is dete...

Full description

Bibliographic Details
Main Author:	Gold, Daniel A.
Format:	Others
Published:	2010
Online Access:	https://thesis.library.caltech.edu/5328/6/Gold_Daniel__2010.pdf Gold, Daniel A. (2010) Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/XG90-5475. https://resolver.caltech.edu/CaltechTHESIS:10232009-160656505 <https://resolver.caltech.edu/CaltechTHESIS:10232009-160656505>

Similar Items

Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae
by: Jessica R. Eisenstatt, et al.
Published: (2020-06-01)

Development of a Screening Method for Discovering Drugs to Interrupt Human Cdc7 Kinase Interaction with Dbf4/Drf1
by: Yi-Sheng Lin, et al.

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
by: Chi-Chun Yang, et al.
Published: (2016-07-01)

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases
by: Heller, Ryan C., et al.
Published: (2013)

The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.
by: Nanda Kumar Sasi, et al.
Published: (2014-01-01)

The Roles of Conserved Dbf4 Motifs in DNA Replication and Checkpoint Responses in Saccharomyces cerevisiae
by: Prasad, Ajai Anand
Published: (2010)

The Roles of Conserved Dbf4 Motifs in DNA Replication and Checkpoint Responses in Saccharomyces cerevisiae
by: Prasad, Ajai Anand
Published: (2010)

Characterization of Dbf4 structure and function in Saccharomyces cerevisiae DNA replication and checkpoint responses.
by: Jones, Darryl
Published: (2014)

Mechanisms Governing DDK Regulation of the Initiation of DNA Replication
by: Larasati, et al.
Published: (2016-12-01)

Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase
by: Branzei, D., et al.
Published: (2022)

Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells
by: Chi-Chun Yang, et al.
Published: (2019-12-01)

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner
by: Julien N. Bianco, et al.
Published: (2019-02-01)

Organization of DNA Replication Origin Firing in <i>Xenopus</i> Egg Extracts: The Role of Intra-S Checkpoint
by: Diletta Ciardo, et al.
Published: (2021-08-01)

DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling
by: Nanda Kumar Sasi, et al.
Published: (2018-10-01)

Phosphorylation of the replicative helicase by the S-phase kinase, Dbf4-Cdc7, at origins of replication in Saccharomyces cerevisiae
by: Francis, Laura Ileana
Published: (2009)

The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.
by: Juergen Zech, et al.
Published: (2015-01-01)

Cell cycle regulation of DNA replication in Xenopus egg extracts
by: Romanowski, Piotr
Published: (1998)

Cdc7-Dbf4 Phosphorylates HSP90 to Regulate the ATR-mediated S-phase checkpoint
by: Cheng, An Ning, et al.
Published: (2015)

Regulation of Protein Kinase Dbf2 in Mitotic Exit
by: Mah, Angie Siu Yee
Published: (2005)

Cdc7-Dbf4 kinase regulates ATR-mediated Mre11 phosphorylation during homologous recombination repair under replication stress
by: 連益歆
Published: (2014)

Regulation of DNA replication in Xenopus
by: Pedro Miguel Barbosa Silva
Published: (2019)

Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity
by: Anoushka Davé, et al.
Published: (2014-04-01)

Molecular analysis of claspin function in vertebrate cells
by: Larkin, Conor
Published: (2010)

Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53
by: Syafiq Abd Wahab, et al.
Published: (2020-07-01)

A Role for Protein Kinase Dbf2-Mob1 in Mitotic Exit
by: Chang, Kuang-Jung
Published: (2012)

The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion.
by: Andrea Koenen, et al.
Published: (2017-01-01)

The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
by: Adjerid, Nassiba
Published: (2014)

A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis
by: Christo P. Christov, et al.
Published: (2018-02-01)

The microinjection of nuclei and DNA into the eggs and oocytes of Xenopus laevis
by: Colman, Alan
Published: (1975)

DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7
by: Lorraine De Jesús-Kim, et al.
Published: (2021-02-01)

Quantitative Analysis of a Cell Cycle Checkpoint in Xenopus laevis Cell-Free Egg Extracts
by: Auckland, Ian
Published: (2014)

The role of Xenopus MCM3 in regulating DNA replication
by: Khoo, Chong-Yee
Published: (1996)

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication
by: Swagata Halder, et al.
Published: (2019-07-01)

Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.
by: Charles T Miller, et al.
Published: (2009-05-01)

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1
by: Robert C. Alver, et al.
Published: (2017-03-01)

Recovery from the DNA Replication Checkpoint
by: Indrajit Chaudhury, et al.
Published: (2016-10-01)

Realization of DBF-OFDM transceiver using FPGA
by: Wei-Lun Weng, et al.
Published: (2011)

Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins
by: Haiyang Zhang, et al.
Published: (2019-05-01)

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repair.
by: Natasha C Koussa, et al.
Published: (2021-01-01)

Comparison between DRF for displacement and acceleration spectra with uncertain damping for EC8
by: Baizid BENAHMED, et al.
Published: (2019-10-01)