Computational Microscopy: Breaking the Limit of Conventional Optics

• Main Author: Ou, Xiaoze
• Format: Others
• Published: 2016
• Online Access: https://thesis.library.caltech.edu/9688/1/Xiaoze_Thesis_Caltech_04282016.pdf; Ou, Xiaoze (2016) Computational Microscopy: Breaking the Limit of Conventional Optics. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z9M32SRZ. https://resolver.caltech.edu/CaltechTHESIS:04282016-051723211 <https://resolver.caltech.edu/CaltechTHESIS:04282016-051723211>

Computational imaging is flourishing thanks to the recent advancement in array photodetectors and image processing algorithms. This thesis presents Fourier ptychography, which is a computational imaging technique implemented in microscopy to break the limit of conventional optics. With the implementation of Fourier ptychography, the resolution of the imaging system can surpass the diffraction limit of the objective lens's numerical aperture; the quantitative phase information of a sample can be reconstructed from intensity-only measurements; and the aberration of a microscope system can be characterized and computationally corrected. This computational microscopy technique enhances the performance of conventional optical systems and expands the scope of their applications.