Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results
Background The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. Method A systematic review and meta-analysis was conducted of representa...
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ndltd-DRESDEN-oai-qucosa.de-bsz-14-qucosa-1173292013-07-06T03:07:22Z Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results Kaymaz, N. Drukker, M. Lieb, Roselind Wittchen, Hans-Ulrich Werbeloff, N. Weiser, M. Lataster, T. van Os, J. Wahnvorstellungen Halluzinationen Meta-Analyse Prävention psychotische Störungen Risiko Delusions hallucinations meta-analysis prevention psychotic disorders risk ddc:150 rvk:CU 3000 Background The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. Method A systematic review and meta-analysis was conducted of representative, longitudinal population-based cohorts with baseline assessment of subthreshold psychotic experiences and follow-up assessment of psychotic and non-psychotic clinical outcomes. Results Six cohorts were identified with a 3–24-year follow-up of baseline subthreshold self-reported psychotic experiences. The yearly risk of conversion to a clinical psychotic outcome in exposed individuals (0.56%) was 3.5 times higher than for individuals without psychotic experiences (0.16%) and there was meta-analytic evidence of dose–response with severity/persistence of psychotic experiences. Individual studies also suggest a role for motivational impairment and social dysfunction. The evidence for conversion to non-psychotic outcome was weaker, although findings were similar in direction. Conclusions Subthreshold self-reported psychotic experiences in epidemiological non-help-seeking samples index psychometric risk for psychotic disorder, with strong modifier effects of severity/persistence. These data can serve as the population reference for selected and variable samples of help-seeking individuals at ultra-high risk, for whom much higher transition rates have been indicated. Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften 2013-07-02 doc-type:article application/pdf http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-117329 urn:nbn:de:bsz:14-qucosa-117329 PPN386857970 http://www.qucosa.de/fileadmin/data/qucosa/documents/11732/1415.pdf Psychological Medicine, Bd. 42 (2012), Nr. 11, S. 2239-2253, ISSN: 0033-2917 eng |
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language |
English |
format |
Article |
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topic |
Wahnvorstellungen Halluzinationen Meta-Analyse Prävention psychotische Störungen Risiko Delusions hallucinations meta-analysis prevention psychotic disorders risk ddc:150 rvk:CU 3000 |
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Wahnvorstellungen Halluzinationen Meta-Analyse Prävention psychotische Störungen Risiko Delusions hallucinations meta-analysis prevention psychotic disorders risk ddc:150 rvk:CU 3000 Kaymaz, N. Drukker, M. Lieb, Roselind Wittchen, Hans-Ulrich Werbeloff, N. Weiser, M. Lataster, T. van Os, J. Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results |
description |
Background The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown.
Method A systematic review and meta-analysis was conducted of representative, longitudinal population-based cohorts with baseline assessment of subthreshold psychotic experiences and follow-up assessment of psychotic and non-psychotic clinical outcomes.
Results Six cohorts were identified with a 3–24-year follow-up of baseline subthreshold self-reported psychotic experiences. The yearly risk of conversion to a clinical psychotic outcome in exposed individuals (0.56%) was 3.5 times higher than for individuals without psychotic experiences (0.16%) and there was meta-analytic evidence of dose–response with severity/persistence of psychotic experiences. Individual studies also suggest a role for motivational impairment and social dysfunction. The evidence for conversion to non-psychotic outcome was weaker, although findings were similar in direction.
Conclusions Subthreshold self-reported psychotic experiences in epidemiological non-help-seeking samples index psychometric risk for psychotic disorder, with strong modifier effects of severity/persistence. These data can serve as the population reference for selected and variable samples of help-seeking individuals at ultra-high risk, for whom much higher transition rates have been indicated. |
author2 |
Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften |
author_facet |
Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften Kaymaz, N. Drukker, M. Lieb, Roselind Wittchen, Hans-Ulrich Werbeloff, N. Weiser, M. Lataster, T. van Os, J. |
author |
Kaymaz, N. Drukker, M. Lieb, Roselind Wittchen, Hans-Ulrich Werbeloff, N. Weiser, M. Lataster, T. van Os, J. |
author_sort |
Kaymaz, N. |
title |
Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results |
title_short |
Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results |
title_full |
Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results |
title_fullStr |
Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results |
title_full_unstemmed |
Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results |
title_sort |
do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? a systematic review and meta-analysis, enriched with new results |
publisher |
Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden |
publishDate |
2013 |
url |
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-117329 http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-117329 http://www.qucosa.de/fileadmin/data/qucosa/documents/11732/1415.pdf |
work_keys_str_mv |
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