Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients
Parkinson’s disease (PD) is frequently compounded by neruropsychiatric complications, increasing disability. The combined effect of motor and mental status on care-dependency in PD outpatients is not well characterized. We conducted a cross-sectional study of 1449 PD outpatients. The assessment comp...
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ndltd-DRESDEN-oai-qucosa.de-bsz-14-qucosa-1200692013-08-27T03:09:25Z Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients Riedel, Oliver Dodel, Richard Deuschl, Günther Klotsche, Jens Förstl, Hans Heuser, Isabella Oertel, Wolfgang H. Reichmann, Heinz Riederer, Peter Trenkwalder, Claudia Wittchen, Hans-Ulrich Depression Parkinson Demenz Pflege Depression Parkinson’s disease Dementia Care ddc:616.833 rvk:YG 5500 Parkinson’s disease (PD) is frequently compounded by neruropsychiatric complications, increasing disability. The combined effect of motor and mental status on care-dependency in PD outpatients is not well characterized. We conducted a cross-sectional study of 1449 PD outpatients. The assessment comprised the Montgomery–Asberg Depression Rating Scale (MADRS) and the diagnostic criteria for dementia. PD severity and treatment complications were rated using Hoehn and Yahr staging and the Unified Parkinson’s Disease Rating Scale (UPDRS) IV. The acknowledged level of care-dependency was documented. Care-dependency was present in 18.3% of all patients. A total of 13.9% had dementia, 18.8% had depression, and 14.3% had both. Regression analyses revealed increasing effects of age, PD duration, and PD severity on care-dependency in all three mental-disorder subgroups with the strongest effects in patients with depression only. Depressed patients with antidepressive treatment still had significantly higher PD severity, higher MADRS and UPDRS-IV scores but were not more likely to be care-dependent than non-depressed patients. Older age, longer duration and increased severity of PD contribute to care-dependency in patients with untreated depression. Treatment of depression is associated with lower rates of care-dependency. Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften 2013-08-15 doc-type:article application/pdf http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-120069 urn:nbn:de:bsz:14-qucosa-120069 PPN39270398X http://www.qucosa.de/fileadmin/data/qucosa/documents/12006/1413_PP.pdf Parkinsonism & Related Disorders, Bd. 18 (2012), Nr. 5, S. 598-601, ISSN: 1353-8020 eng |
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English |
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Depression Parkinson Demenz Pflege Depression Parkinson’s disease Dementia Care ddc:616.833 rvk:YG 5500 |
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Depression Parkinson Demenz Pflege Depression Parkinson’s disease Dementia Care ddc:616.833 rvk:YG 5500 Riedel, Oliver Dodel, Richard Deuschl, Günther Klotsche, Jens Förstl, Hans Heuser, Isabella Oertel, Wolfgang H. Reichmann, Heinz Riederer, Peter Trenkwalder, Claudia Wittchen, Hans-Ulrich Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients |
description |
Parkinson’s disease (PD) is frequently compounded by neruropsychiatric complications, increasing disability. The combined effect of motor and mental status on care-dependency in PD outpatients is not well characterized. We conducted a cross-sectional study of 1449 PD outpatients. The assessment comprised the Montgomery–Asberg Depression Rating Scale (MADRS) and the diagnostic criteria for dementia. PD severity and treatment complications were rated using Hoehn and Yahr staging and the Unified Parkinson’s Disease Rating Scale (UPDRS) IV. The acknowledged level of care-dependency was documented. Care-dependency was present in 18.3% of all patients. A total of 13.9% had dementia, 18.8% had depression, and 14.3% had both. Regression analyses revealed increasing effects of age, PD duration, and PD severity on care-dependency in all three mental-disorder subgroups with the strongest effects in patients with depression only. Depressed patients with antidepressive treatment still had significantly higher PD severity, higher MADRS and UPDRS-IV scores but were not more likely to be care-dependent than non-depressed patients. Older age, longer duration and increased severity of PD contribute to care-dependency in patients with untreated depression. Treatment of depression is associated with lower rates of care-dependency. |
author2 |
Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften |
author_facet |
Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften Riedel, Oliver Dodel, Richard Deuschl, Günther Klotsche, Jens Förstl, Hans Heuser, Isabella Oertel, Wolfgang H. Reichmann, Heinz Riederer, Peter Trenkwalder, Claudia Wittchen, Hans-Ulrich |
author |
Riedel, Oliver Dodel, Richard Deuschl, Günther Klotsche, Jens Förstl, Hans Heuser, Isabella Oertel, Wolfgang H. Reichmann, Heinz Riederer, Peter Trenkwalder, Claudia Wittchen, Hans-Ulrich |
author_sort |
Riedel, Oliver |
title |
Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients |
title_short |
Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients |
title_full |
Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients |
title_fullStr |
Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients |
title_full_unstemmed |
Depression and care-dependency in Parkinson’s disease: Results from a nationwide study of 1449 outpatients |
title_sort |
depression and care-dependency in parkinson’s disease: results from a nationwide study of 1449 outpatients |
publisher |
Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden |
publishDate |
2013 |
url |
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-120069 http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-120069 http://www.qucosa.de/fileadmin/data/qucosa/documents/12006/1413_PP.pdf |
work_keys_str_mv |
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