Epidemiology and recurrence rates of Clostridium difficile infections in Germany
Clostridium difficile infection (CDI) is the most common cause of health-care-associated infectious diarrhea. Recurrence rates are as high as 20–30% after standard treatment with metronidazole or vancomycin, and appear to be reduced for patients treated with fidaxomicin. According to the literature,...
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Universitätsbibliothek Leipzig
2016
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ndltd-DRESDEN-oai-qucosa.de-bsz-15-qucosa-2138782016-11-23T03:30:30Z Epidemiology and recurrence rates of Clostridium difficile infections in Germany Lübbert, Christoph Zimmermann, Lisa Borchert, Julia Hörner, Bernd Mutters, Reinier Rodloff, Arne C. bakterielle Infektion Clostridium difficile Deutschland bacterial infection Clostridium difficile Germany ddc:601 Clostridium difficile infection (CDI) is the most common cause of health-care-associated infectious diarrhea. Recurrence rates are as high as 20–30% after standard treatment with metronidazole or vancomycin, and appear to be reduced for patients treated with fidaxomicin. According to the literature, the risk of CDI recurrence increases after the second relapse to 30–65%. Accurate data for Germany are not yet available. Methods: Based on the research database of arvato health analytics (Munich, Germany), a secondary data analysis for the incidence, treatment characteristics and course of CDI was performed. The database included high granular accounting information of about 1.46 million medically insured patients covering the period 2006–2013, being representative for Germany. The analysis was based on new-onset CDI in 2012 in patients which either received outpatient antibiotic therapy for CDI or were hospitalized. Results: The ICD-10 coded incidence of CDI in 2012 was 83 cases per 100,000 population. Universitätsbibliothek Leipzig Universität Leipzig, Medizinische Fakultät Universität Leipzig, Medizinische Fakultät Gesundheitsforen Leipzig GmbH, MSD Sharp & Dohme, Philipps-Universität Marburg, Institut für Medizinische Mikrobiologie und Hygiene Universität Leipzig, Medizinische Fakultät Springer, 2016-11-22 doc-type:article application/pdf http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-213878 urn:nbn:de:bsz:15-qucosa-213878 http://www.qucosa.de/fileadmin/data/qucosa/documents/21387/OAP-2016-172_L%C3%BCbbert_OM_CDI_Inf_Dis_Ther_2016.pdf Infectious diseases and therapy doi: 10.1007/s40121-016-0135-9 eng |
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English |
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bakterielle Infektion Clostridium difficile Deutschland bacterial infection Clostridium difficile Germany ddc:601 |
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bakterielle Infektion Clostridium difficile Deutschland bacterial infection Clostridium difficile Germany ddc:601 Lübbert, Christoph Zimmermann, Lisa Borchert, Julia Hörner, Bernd Mutters, Reinier Rodloff, Arne C. Epidemiology and recurrence rates of Clostridium difficile infections in Germany |
description |
Clostridium difficile infection (CDI) is the most common cause of health-care-associated infectious diarrhea. Recurrence rates are as high as 20–30% after standard treatment with metronidazole or vancomycin, and appear to be reduced for patients treated with fidaxomicin. According to the literature, the risk of CDI recurrence increases after the second relapse to 30–65%. Accurate data for Germany are not yet available. Methods: Based on the research database of arvato health analytics (Munich, Germany), a secondary data analysis for the incidence, treatment characteristics and course of CDI was performed. The database included high granular accounting information of about 1.46 million medically insured patients covering the period 2006–2013, being representative for Germany. The analysis was based on new-onset CDI in 2012 in patients which either received outpatient antibiotic therapy for CDI or were hospitalized. Results: The ICD-10 coded incidence of CDI in 2012 was 83 cases per 100,000 population. |
author2 |
Universität Leipzig, Medizinische Fakultät |
author_facet |
Universität Leipzig, Medizinische Fakultät Lübbert, Christoph Zimmermann, Lisa Borchert, Julia Hörner, Bernd Mutters, Reinier Rodloff, Arne C. |
author |
Lübbert, Christoph Zimmermann, Lisa Borchert, Julia Hörner, Bernd Mutters, Reinier Rodloff, Arne C. |
author_sort |
Lübbert, Christoph |
title |
Epidemiology and recurrence rates of Clostridium difficile infections in Germany |
title_short |
Epidemiology and recurrence rates of Clostridium difficile infections in Germany |
title_full |
Epidemiology and recurrence rates of Clostridium difficile infections in Germany |
title_fullStr |
Epidemiology and recurrence rates of Clostridium difficile infections in Germany |
title_full_unstemmed |
Epidemiology and recurrence rates of Clostridium difficile infections in Germany |
title_sort |
epidemiology and recurrence rates of clostridium difficile infections in germany |
publisher |
Universitätsbibliothek Leipzig |
publishDate |
2016 |
url |
http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-213878 http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-213878 http://www.qucosa.de/fileadmin/data/qucosa/documents/21387/OAP-2016-172_L%C3%BCbbert_OM_CDI_Inf_Dis_Ther_2016.pdf |
work_keys_str_mv |
AT lubbertchristoph epidemiologyandrecurrenceratesofclostridiumdifficileinfectionsingermany AT zimmermannlisa epidemiologyandrecurrenceratesofclostridiumdifficileinfectionsingermany AT borchertjulia epidemiologyandrecurrenceratesofclostridiumdifficileinfectionsingermany AT hornerbernd epidemiologyandrecurrenceratesofclostridiumdifficileinfectionsingermany AT muttersreinier epidemiologyandrecurrenceratesofclostridiumdifficileinfectionsingermany AT rodloffarnec epidemiologyandrecurrenceratesofclostridiumdifficileinfectionsingermany |
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