Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing

<p>Humans and animals have remarkable capabilities in keeping time and using time as a guide to orient their learning and decision making. Psychophysical models of timing and time perception have been proposed for decades and have received behavioral, anatomical and pharmacological data suppor...

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Main Author: Yin, Bin Yin
Other Authors: Meck, Warren H.
Published: 2016
Subjects:
Online Access:http://hdl.handle.net/10161/12286
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spelling ndltd-DUKE-oai-dukespace.lib.duke.edu-10161-122862016-06-08T03:30:26ZContributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval TimingYin, Bin YinPsychologyNeurosciencesClaustrumConsciousnessHippocampusStriatumTime perceptionTiming<p>Humans and animals have remarkable capabilities in keeping time and using time as a guide to orient their learning and decision making. Psychophysical models of timing and time perception have been proposed for decades and have received behavioral, anatomical and pharmacological data support. However, despite numerous studies that aimed at delineating the neural underpinnings of interval timing, a complete picture of the neurobiological network of timing in the seconds-to-minutes range remains elusive. Based on classical interval timing protocols and proposing a Timing, Immersive Memory and Emotional Regulation (TIMER) test battery, the author investigates the contributions of the dorsal and ventral hippocampus as well as the dorsolateral and the dorsomedial striatum to interval timing by comparing timing performances in mice after they received cytotoxic lesions in the corresponding brain regions. On the other hand, a timing-based theoretical framework for the emergence of conscious experience that is closely related to the function of the claustrum is proposed so as to serve both biological guidance and the research and evolution of “strong” artificial intelligence. Finally, a new “Double Saturation Model of Interval Timing” that integrates the direct- and indirect- pathways of striatum is proposed to explain the set of empirical findings.</p>DissertationMeck, Warren H.2016Dissertationhttp://hdl.handle.net/10161/12286
collection NDLTD
sources NDLTD
topic Psychology
Neurosciences
Claustrum
Consciousness
Hippocampus
Striatum
Time perception
Timing
spellingShingle Psychology
Neurosciences
Claustrum
Consciousness
Hippocampus
Striatum
Time perception
Timing
Yin, Bin Yin
Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing
description <p>Humans and animals have remarkable capabilities in keeping time and using time as a guide to orient their learning and decision making. Psychophysical models of timing and time perception have been proposed for decades and have received behavioral, anatomical and pharmacological data support. However, despite numerous studies that aimed at delineating the neural underpinnings of interval timing, a complete picture of the neurobiological network of timing in the seconds-to-minutes range remains elusive. Based on classical interval timing protocols and proposing a Timing, Immersive Memory and Emotional Regulation (TIMER) test battery, the author investigates the contributions of the dorsal and ventral hippocampus as well as the dorsolateral and the dorsomedial striatum to interval timing by comparing timing performances in mice after they received cytotoxic lesions in the corresponding brain regions. On the other hand, a timing-based theoretical framework for the emergence of conscious experience that is closely related to the function of the claustrum is proposed so as to serve both biological guidance and the research and evolution of “strong” artificial intelligence. Finally, a new “Double Saturation Model of Interval Timing” that integrates the direct- and indirect- pathways of striatum is proposed to explain the set of empirical findings.</p> === Dissertation
author2 Meck, Warren H.
author_facet Meck, Warren H.
Yin, Bin Yin
author Yin, Bin Yin
author_sort Yin, Bin Yin
title Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing
title_short Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing
title_full Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing
title_fullStr Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing
title_full_unstemmed Contributions of Dorsal/Ventral Hippocampus and Dorsolateral/Dorsomedial Striatum to Interval Timing
title_sort contributions of dorsal/ventral hippocampus and dorsolateral/dorsomedial striatum to interval timing
publishDate 2016
url http://hdl.handle.net/10161/12286
work_keys_str_mv AT yinbinyin contributionsofdorsalventralhippocampusanddorsolateraldorsomedialstriatumtointervaltiming
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