Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics

Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics

Carbon dots (CDs) have attracted much attention as an excellent gene/drug delivery and biological imaging agent for early cancer theranostics. In this study, we prepared two series of nanoparticles (NPs), which are composed of (CDs) with a targeting agent, folic acid (FA), and a chemotherapeutic age...

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Bibliographic Details
Main Author: Dada, Samson
Format: Others
Language:English
Published: Digital Commons @ East Tennessee State University 2019
Subjects:
carbon dots
nanoparticles
theranostics
cancer
chemotherapeutic
doxorubicin
Materials Chemistry
Organic Chemistry
Online Access:https://dc.etsu.edu/etd/3671
https://dc.etsu.edu/cgi/viewcontent.cgi?article=5149&context=etd
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spelling ndltd-ETSU-oai-dc.etsu.edu-etd-51492021-01-12T05:05:05Z Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics Dada, Samson Carbon dots (CDs) have attracted much attention as an excellent gene/drug delivery and biological imaging agent for early cancer theranostics. In this study, we prepared two series of nanoparticles (NPs), which are composed of (CDs) with a targeting agent, folic acid (FA), and a chemotherapeutic agent Doxorubicin (Dox). All the NPs and their intermediates were characterized using ultraviolet-visible spectroscopy (UV-vis), fluorescence spectroscopy, and Fourier transform-infrared spectroscopy (FT-IR). The drug loading capacity (DLC) and drug loading efficiency (DLE) of two series of FA-CDs-Dox were assessed using UV-vis absorption spectroscopy at the wavelength of 485 nm. Both showed good DLE and DLC results when compared to literature data. In addition, the cumulative release property of Dox from the FA-CDs-Dox complexes were investigated in a pH solution of 7.4. 2019-12-01T08:00:00Z text application/pdf https://dc.etsu.edu/etd/3671 https://dc.etsu.edu/cgi/viewcontent.cgi?article=5149&context=etd Copyright by the authors. Electronic Theses and Dissertations eng Digital Commons @ East Tennessee State University carbon dots nanoparticles theranostics cancer chemotherapeutic doxorubicin Materials Chemistry Organic Chemistry
collection NDLTD
language English
format Others
sources NDLTD
topic carbon dots
nanoparticles
theranostics
cancer
chemotherapeutic
doxorubicin
Materials Chemistry
Organic Chemistry
spellingShingle carbon dots
nanoparticles
theranostics
cancer
chemotherapeutic
doxorubicin
Materials Chemistry
Organic Chemistry
Dada, Samson
Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics
description Carbon dots (CDs) have attracted much attention as an excellent gene/drug delivery and biological imaging agent for early cancer theranostics. In this study, we prepared two series of nanoparticles (NPs), which are composed of (CDs) with a targeting agent, folic acid (FA), and a chemotherapeutic agent Doxorubicin (Dox). All the NPs and their intermediates were characterized using ultraviolet-visible spectroscopy (UV-vis), fluorescence spectroscopy, and Fourier transform-infrared spectroscopy (FT-IR). The drug loading capacity (DLC) and drug loading efficiency (DLE) of two series of FA-CDs-Dox were assessed using UV-vis absorption spectroscopy at the wavelength of 485 nm. Both showed good DLE and DLC results when compared to literature data. In addition, the cumulative release property of Dox from the FA-CDs-Dox complexes were investigated in a pH solution of 7.4.
author Dada, Samson
author_facet Dada, Samson
author_sort Dada, Samson
title Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics
title_short Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics
title_full Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics
title_fullStr Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics
title_full_unstemmed Preparation of Folic Acid-Carbon Dots-Doxorubicin Nanoparticles as Targeting Tumor Theranostics
title_sort preparation of folic acid-carbon dots-doxorubicin nanoparticles as targeting tumor theranostics
publisher Digital Commons @ East Tennessee State University
publishDate 2019
url https://dc.etsu.edu/etd/3671
https://dc.etsu.edu/cgi/viewcontent.cgi?article=5149&context=etd
work_keys_str_mv AT dadasamson preparationoffolicacidcarbondotsdoxorubicinnanoparticlesastargetingtumortheranostics
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