Osteopontin: Role in Extracellular Matrix Deposition and Myocardial Remodeling Post-MI

• Main Authors: Singh, Mahipal, Foster, Cerrone R., Dalal, Suman, Singh, Krishna
• Format: Others
• Published: Digital Commons @ East Tennessee State University 2010
• Subjects: ECM; MMPs; myocardial infarction; myocardial remodeling; osteopontin; Biological Sciences; Biomedical Sciences; Health Sciences
• Online Access: https://dc.etsu.edu/etsu-works/8576; https://dc.etsu.edu/cgi/viewcontent.cgi?article=9840&context=etsu-works

Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and improved LV function in mice lacking OPN after MI. This review summarizes — 1) signaling pathways leading to increased expression of OPN in the heart; 2) the alterations in the structure and function of the heart post-MI in mice lacking OPN; and 3) mechanisms involved in OPN-mediated ECM remodeling post-MI.