Engineering ligand-receptor pairs for small molecule control of transcription
Creating receptors for control of transcription with arbitrary small molecules has widespread applications including gene therapy, biosensors, and enzyme engineering. Using the combination of high throughput docking, codon randomization, and chemical complementation, we have created new receptors...
Main Author: | Schwimmer, Lauren J. |
---|---|
Format: | Others |
Language: | en_US |
Published: |
Georgia Institute of Technology
2006
|
Subjects: | |
Online Access: | http://hdl.handle.net/1853/11651 |
Similar Items
-
Engineering a better receptor: characterization of retinoid x receptor alpha and functional variants
by: Watt, Terry J.
Published: (2009) -
Engineering the pregnane X receptor and estrogen receptor alpha to bind novel small molecules using negative chemical complementation
by: Shaffer, Hally A.
Published: (2011) -
Mutational analysis and engineering of the human vitamin D receptor to bind and activate in response to a novel small molecule ligand
by: Castillo, Hilda S.
Published: (2011) -
Extending chemical complemenation to bacteria and furthering nuclear receptor based protein engineering and drug discovery
by: Johnson, Kenyetta Alicia
Published: (2009) -
Vitamin A and retinoid signaling: genomic and nongenomic effects
by: Ziad Al Tanoury, et al.
Published: (2013-07-01)