Delivery of thermostabilized chondroitinase ABC enhances axonal sprouting and functional recovery after spinal cord injury

Delivery of thermostabilized chondroitinase ABC enhances axonal sprouting and functional recovery after spinal cord injury

Chondroitin sulfate proteoglycans (CSPGs) are one major class of axon growth inhibitors that are upregulated and accumulated around the lesion site after spinal cord injury (SCI), and result in regenerative failure. To overcome CSPG-mediated inhibition, digestion of CSPGs with chondroitinase ABC (ch...

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Bibliographic Details
Main Author: Lee, Hyun-Jung
Published: Georgia Institute of Technology 2010
Subjects:
Lipid microtube
Hydrogel
Regeneration
Chondroitin sulfate proteoglycan
Spinal cord injury
Chondroitinase ABC
Chondroitin sulfates
Protein engineering
Spinal cord Wounds and injuries
Spinal cord Regeneration
Online Access:http://hdl.handle.net/1853/31734

Internet

http://hdl.handle.net/1853/31734

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