Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers
The analysis and development of robust sensing platforms based on solidly-mounted ZnO bulk acoustic wave devices was proposed. The exploitation of acoustic energy trapping was investigated and demonstrated as a method to define active sensing areas on a substrate. In addition, a new "hybrid&q...
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ndltd-GATECH-oai-smartech.gatech.edu-1853-427172013-01-07T20:38:07ZAcoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkersWathen, Adam DanielZNOBulk acoustic waveEnergy trappingAcoustic sensorsBiosensorsBulk acoustic delay lineSMRBiosensorsBiochemical markersTumor markersAcoustic surface wave devicesThe analysis and development of robust sensing platforms based on solidly-mounted ZnO bulk acoustic wave devices was proposed. The exploitation of acoustic energy trapping was investigated and demonstrated as a method to define active sensing areas on a substrate. In addition, a new "hybrid" acoustic mode experiencing acoustic energy trapping was studied theoretically and experimentally. This mode was used as an explanation of historical inconsistencies in observed thickness-shear mode velocities. Initial theoretical and experimental results suggest that this mode is a coupling of thickness-shear and longitudinal particle displacements and, as such, may offer more mechanical and/or structural information about a sample under test. Device development was taken another step further and multi-mode ZnO resonators operating in the thickness-shear, hybrid, and longitudinal modes were introduced. These devices were characterized with respect to sample viscosity and conductivity and preliminary results show that, with further development, the multi-mode resonators provide significantly more information about a sample than their single-mode counterparts. An alternative to resonator-based platforms was also presented in the form of bulk acoustic delay lines. Initial conceptual and simulation results show that these devices provide a different perspective of typical sensing modalities by using properly designed input pulses, device tuning, and examining overall input and output signal spectra.Georgia Institute of Technology2012-02-17T19:14:51Z2012-02-17T19:14:51Z2011-08-11Dissertationhttp://hdl.handle.net/1853/42717 |
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ZNO Bulk acoustic wave Energy trapping Acoustic sensors Biosensors Bulk acoustic delay line SMR Biosensors Biochemical markers Tumor markers Acoustic surface wave devices |
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ZNO Bulk acoustic wave Energy trapping Acoustic sensors Biosensors Bulk acoustic delay line SMR Biosensors Biochemical markers Tumor markers Acoustic surface wave devices Wathen, Adam Daniel Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers |
description |
The analysis and development of robust sensing platforms based on solidly-mounted ZnO bulk acoustic wave devices was proposed. The exploitation of acoustic energy trapping was investigated and demonstrated as a method to define active sensing areas on a substrate. In addition, a new "hybrid" acoustic mode experiencing acoustic energy trapping was studied theoretically and experimentally. This mode was used as an explanation of historical inconsistencies in observed thickness-shear mode velocities. Initial theoretical and experimental results suggest that this mode is a coupling of thickness-shear and longitudinal particle displacements and, as such, may offer more mechanical and/or structural information about a sample under test. Device development was taken another step further and multi-mode ZnO resonators operating in the thickness-shear, hybrid, and longitudinal modes were introduced. These devices were characterized with respect to sample viscosity and conductivity and preliminary results show that, with further development, the multi-mode resonators provide significantly more information about a sample than their single-mode counterparts. An alternative to resonator-based platforms was also presented in the form of bulk acoustic delay lines. Initial conceptual and simulation results show that these devices provide a different perspective of typical sensing modalities by using properly designed input pulses, device tuning, and examining overall input and output signal spectra. |
author |
Wathen, Adam Daniel |
author_facet |
Wathen, Adam Daniel |
author_sort |
Wathen, Adam Daniel |
title |
Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers |
title_short |
Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers |
title_full |
Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers |
title_fullStr |
Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers |
title_full_unstemmed |
Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers |
title_sort |
acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers |
publisher |
Georgia Institute of Technology |
publishDate |
2012 |
url |
http://hdl.handle.net/1853/42717 |
work_keys_str_mv |
AT wathenadamdaniel acousticwavebiosensorarraysforthesimultaneousdetectionofmultiplecancerbiomarkers |
_version_ |
1716475607509893120 |