Photocleavable Linker for Protein Affinity Labeling to Identify the Binding Target of KCN-1
KCN-1 is known to reduce tumor growth 6-fold in mice implanted with LN229 glioma cells. Although this inhibitor is effective, the mechanism of action for KCN-1 is not well understood. Based on preliminary studies, KCN-1 reduces tumor growth by disrupting the HIF 1 (hypoxia-induced factor-1) pathwa...
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| Format: | Others |
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Digital Archive @ GSU
2010
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| Online Access: | http://digitalarchive.gsu.edu/chemistry_theses/35 http://digitalarchive.gsu.edu/cgi/viewcontent.cgi?article=1034&context=chemistry_theses |