Síntese de hidrazonas, semicarbazonas e tiossemicarbazonas de indirubinas 5-substituídas

• Main Author: Souza, Ana Carolina Carbonaro
• Other Authors: Grazul, Richard Michael
• Language: Portuguese
• Published: Universidade Federal de Juiz de Fora (UFJF) 2017
• Subjects: CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA; Indirubina; Índigo; Semicarbazonas; Tiossemicarbazonas; Antineoplásicos
• Online Access: https://repositorio.ufjf.br/jspui/handle/ufjf/4231

Submitted by Renata Lopes ([e-mail]) on 2017-05-10T19:45:56Z No. of bitstreams: 1 anacarolinacarbonarosouza.pdf: 5273053 bytes, checksum: b5d4d12df8d11a927138183281032371 (MD5) === Approved for entry into archive by Adriana Oliveira ([e-mail]) on 2017-05-11T13:28:02Z (GMT) No. of bitstreams: 1 anacarolinacarbonarosouza.pdf: 5273053 bytes, checksum: b5d4d12df8d11a927138183281032371 (MD5) === Made available in DSpace on 2017-05-11T13:28:02Z (GMT). No. of bitstreams: 1 anacarolinacarbonarosouza.pdf: 5273053 bytes, checksum: b5d4d12df8d11a927138183281032371 (MD5) Previous issue date: 2017-03-06 === A presente dissertação, intitulada “Síntese de Hidrazonas, Semicarbazonas e Tiossemicarbazonas de Indirubinas 5-substituídas”, descreve a preparação e caracterização de indirubinas associadas a unidades semicarbazonas e tiossemicarbazonas. Duas rotas sintéticas foram examinadas para a obtenção dos compostos-alvo propostos: 1) via reação de adição nucleofílica de indirubinas-3’-hidrazonas a fenilisocianatos e fenilisotiocianatos e 2) pela condensação entre indirubinas-5-substituídas e semicarbazidas e tiossemicarbazidas N-4 substituídas. Os compostos obtidos foram caracterizados pela faixa de fusão, espectroscopia na região do ultravioleta visível, infravermelho, ressonância magnética nuclear de 1H e 13C. === The present dissertation, entitled "Synthesis of Hydrazones, Semicarbazones and Thiosemicarbazones of 5-substituted Indirubines," describes the preparation and characterization of indirubins 3’ hydrazones, semicarbazones and thiosemicarbazones. Two synthetic routes were examined to obtain the proposed target compounds: 1) via the nucleophilic addition reaction of indirubins-3'-hydrazones to phenylisocyanates and phenylisothiocyanates and 2) by the condensation between 5-substituted indirubins and N4semicarbazides and thiosemicarbazides. The compounds obtained were characterized by their melting, ultraviolet-visible and infrared spectroscopies, and 1H and 13C nuclear magnetic resonance.