Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica
Objectives. We sought to evaluate the safety and efficacy of Drug eluting stents (DES) in patients with significant CKD in a real world registry Background. Patients with chronic kidney disease (CKD) who undergo percutaneous coronary angioplasty have higher rates of target lesion revascularization (...
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ndltd-IBICT-oai-lume.ufrgs.br-10183-174332018-10-21T16:54:32Z Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica Blaya, Patrícia Caramori, Paulo Ricardo Avancini Insuficiência renal crônica Stents farmacológicos Objectives. We sought to evaluate the safety and efficacy of Drug eluting stents (DES) in patients with significant CKD in a real world registry Background. Patients with chronic kidney disease (CKD) who undergo percutaneous coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. DES are associated with a lower rate of restenosis compared to bare metal stents (BMS), although in patients with CKD data on DES efficacy and safety is limited. Methods. A total of 504 patients who underwent percutaneous coronary intervention with DES in two centers were included in this study. Outcomes were stratified on the basis of the presence of CKD, defined as a baseline glomerular filtration rate <60ml/min/1.73m². Results. The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had more hypertension and diabetes. CKD patients presented increased incidence of death (12.3% vs. 2.4%, p<0.001) and myocardial infarction (MI) (7.4% vs. 3.3%, p=0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs. 5.6%, p=0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 – 19.5, p<0.001), current smoking (HR 3.66; 1.20 – 11.10, p=0.02) and diabetes (HR 2.66; 1.03 – 6.60, p=0.045). Conclusion. In this real-world registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates. 2009-10-14T04:17:10Z 2008 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis http://hdl.handle.net/10183/17433 000716453 por info:eu-repo/semantics/openAccess application/pdf reponame:Biblioteca Digital de Teses e Dissertações da UFRGS instname:Universidade Federal do Rio Grande do Sul instacron:UFRGS |
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Insuficiência renal crônica Stents farmacológicos |
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Insuficiência renal crônica Stents farmacológicos Blaya, Patrícia Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica |
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Objectives. We sought to evaluate the safety and efficacy of Drug eluting stents (DES) in patients with significant CKD in a real world registry Background. Patients with chronic kidney disease (CKD) who undergo percutaneous coronary angioplasty have higher rates of target lesion revascularization (TLR) and mortality. DES are associated with a lower rate of restenosis compared to bare metal stents (BMS), although in patients with CKD data on DES efficacy and safety is limited. Methods. A total of 504 patients who underwent percutaneous coronary intervention with DES in two centers were included in this study. Outcomes were stratified on the basis of the presence of CKD, defined as a baseline glomerular filtration rate <60ml/min/1.73m². Results. The mean follow-up was 22.7 months. CKD was present in 165 patients (32.7%). Patients with CKD were older, had more hypertension and diabetes. CKD patients presented increased incidence of death (12.3% vs. 2.4%, p<0.001) and myocardial infarction (MI) (7.4% vs. 3.3%, p=0.04) compared to patients without CKD. TLR rates were similar between groups (4.8% vs. 5.6%, p=0.7, CKD and no CKD patients, respectively). Independent predictors of death were CKD (HR 6.93; 2.4 – 19.5, p<0.001), current smoking (HR 3.66; 1.20 – 11.10, p=0.02) and diabetes (HR 2.66; 1.03 – 6.60, p=0.045). Conclusion. In this real-world registry, coronary intervention with DES in patients with CKD was associated with similar TLR compared to patients without CKD, demonstrating the efficacy of DES in preventing in-stent restenosis in this patient population. CKD was related to significantly increased MI and mortality rates. |
author2 |
Caramori, Paulo Ricardo Avancini |
author_facet |
Caramori, Paulo Ricardo Avancini Blaya, Patrícia |
author |
Blaya, Patrícia |
author_sort |
Blaya, Patrícia |
title |
Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica |
title_short |
Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica |
title_full |
Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica |
title_fullStr |
Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica |
title_full_unstemmed |
Eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica |
title_sort |
eficácia e segurança dos stents farmacológicos em pacientes com insuficiência renal crônica |
publishDate |
2009 |
url |
http://hdl.handle.net/10183/17433 |
work_keys_str_mv |
AT blayapatricia eficaciaesegurancadosstentsfarmacologicosempacientescominsuficienciarenalcronica |
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1718778684189442048 |