Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical
CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior === Epilepsy is the most common neurological disorder, affecting 50 million people worldwide, 40 million of them in developed countries. People of all races, genders, socioeconomic conditions and regions are affected. The pilocarpine (P400) is a choli...
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Universidade Federal do CearÃ
2011
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Online Access: | http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9563 |
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Imipenem / cilastatin Meropenem Convulsion. FARMACOLOGIA |
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Imipenem / cilastatin Meropenem Convulsion. FARMACOLOGIA Camila Nayane de Carvalho Lima Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical |
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CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior === Epilepsy is the most common neurological disorder, affecting 50 million people worldwide, 40 million of them in developed countries. People of all races, genders, socioeconomic conditions and regions are affected. The pilocarpine (P400) is a cholinergic agonist characterized by inducing seizures evolving to status epilepticus, similar to human temporal lobe epilepsy. The pentylenetetrazole (PTZ) is a GABA antagonist that mimics the small-mal seizures (absence seizure) and tonic-clonic seizures in humans. The strychnine is a potent convulsant and acts mainly as a selective antagonist of postsynaptic inhibition mediated by glycine. Its main action is to increase the excitability of the spinal reflex . The convulsant picrotoxin is an agent that blocks chloride channels activated by gamma-aminobutyric acid. Convulsant agents were administered intraperitoneally, 10 minutes after intravenous administration of carbapenÃmcios With the development of this work, we found that pretreatment with imipenem or meropenem interfere with various neurotransmitter systems when animals are subjected to seizures induced by pilocarpine at a dose of 400mg/kg, 55mg/Kg at a dose of pentylenetetrazole, strychnine and picrotoxin 10mg/Kg 2mg/kg. This has been evidenced by increasing levels of excitatory amino acids such as glutamate and on the other hand, a decrease in levels of inhibitory amino acids such as GABA reinforcing the existence of a possible modulatory pathway of these amino acids in control and development of seizure occurs when pre-treatment with imipenem or meropenem. === Epilepsia à o mais freqÃente distÃrbio neurolÃgico, atingindo 50 milhÃes de pessoas no mundo, 40 milhÃes delas em paÃses desenvolvidos. Pessoas de todas as raÃas, sexos, condiÃÃes socioeconÃmicas e regiÃes sÃo acometidas. A pilocarpina (P400) à um agonista colinÃrgico que se caracteriza por induzir convulsÃes que evoluem para status epilÃpticus, similar à epilepsia do lobo temporal humana. O pentilenotetrazol (PTZ) à um antagonista GABA que mimetiza convulsÃes do pequeno-mal (crise de ausÃncia) e do tipo tÃnico-clÃnico em humanos. A estricnina à um potente convulsivante e atua, principalmente, como antagonista competitivo seletivo da inibiÃÃo pÃs-sinÃptica mediada pela glicina. Sua principal aÃÃo à o aumento da excitabilidade reflexa da medula. A picrotoxina à um agente convulsivante que bloqueia os canais de cloro ativados pelo Ãcido gama-aminobutÃrico. Os agentes convulsivantes foram administrados intraperitonialmente, apÃs 10 minutos da administraÃÃo intravenosa dos carbapenÃmcios Com o desenvolvimento deste trabalho, podemos observar que o prÃ-tratamento com imipenem ou meropenem interfere com vÃrios sistemas de neurotransmissores quando os animais sÃo submetidos à convulsÃo induzida pela pilocarpina na dose de 400mg/kg, pentilenotetrazol na dose de 55mg/Kg, estricnina 2mg/Kg e picrotoxina 10mg/Kg. Tal efeito foi evidenciado atravÃs do aumento nos nÃveis de aminoÃcidos excitatÃrios como o glutamato e, por outro lado, uma diminuiÃÃo nos nÃveis de aminoÃcidos inibitÃrios como o GABA reforÃando a existÃncia de uma possÃvel via modulatÃria desses aminoÃcidos no controle e desenvolvimento de crises epilÃpticas quando ocorre o prÃ-tratamento com imipenem/cilastatina ou meropenem. |
author2 |
Marta Maria de FranÃa Fonteles |
author_facet |
Marta Maria de FranÃa Fonteles Camila Nayane de Carvalho Lima |
author |
Camila Nayane de Carvalho Lima |
author_sort |
Camila Nayane de Carvalho Lima |
title |
Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical |
title_short |
Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical |
title_full |
Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical |
title_fullStr |
Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical |
title_full_unstemmed |
Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical |
title_sort |
convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical |
publisher |
Universidade Federal do Cearà |
publishDate |
2011 |
url |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9563 |
work_keys_str_mv |
AT camilanayanedecarvalholima convulsantcarbapenemspotentialofdifferentmodelsinexperimentalconvulsionbenchmarkingbehavioralandneurochemical AT camilanayanedecarvalholima potencialconvulsivantedecarbapenamicosemdiferentesmodelosexperimentaisdeconvulsaoavaliaaaocomparativacomportamentaleneuroquamica |
_version_ |
1718900289928429568 |
spelling |
ndltd-IBICT-oai-www.teses.ufc.br-65732019-01-21T22:57:59Z Convulsant carbapenems potential of different models in experimental convulsion: benchmarking, behavioral and neurochemical Potencial convulsivante de carbapenÃmicos em diferentes modelos experimentais de convulsÃo: avaliaÃÃo comparativa, comportamental e neuroquÃmica Camila Nayane de Carvalho Lima Marta Maria de FranÃa Fonteles Danielle MacÃdo Gaspar Hemerson Iury Ferreira MagalhÃes Imipenem / cilastatin Meropenem Convulsion. FARMACOLOGIA CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior Epilepsy is the most common neurological disorder, affecting 50 million people worldwide, 40 million of them in developed countries. People of all races, genders, socioeconomic conditions and regions are affected. The pilocarpine (P400) is a cholinergic agonist characterized by inducing seizures evolving to status epilepticus, similar to human temporal lobe epilepsy. The pentylenetetrazole (PTZ) is a GABA antagonist that mimics the small-mal seizures (absence seizure) and tonic-clonic seizures in humans. The strychnine is a potent convulsant and acts mainly as a selective antagonist of postsynaptic inhibition mediated by glycine. Its main action is to increase the excitability of the spinal reflex . The convulsant picrotoxin is an agent that blocks chloride channels activated by gamma-aminobutyric acid. Convulsant agents were administered intraperitoneally, 10 minutes after intravenous administration of carbapenÃmcios With the development of this work, we found that pretreatment with imipenem or meropenem interfere with various neurotransmitter systems when animals are subjected to seizures induced by pilocarpine at a dose of 400mg/kg, 55mg/Kg at a dose of pentylenetetrazole, strychnine and picrotoxin 10mg/Kg 2mg/kg. This has been evidenced by increasing levels of excitatory amino acids such as glutamate and on the other hand, a decrease in levels of inhibitory amino acids such as GABA reinforcing the existence of a possible modulatory pathway of these amino acids in control and development of seizure occurs when pre-treatment with imipenem or meropenem. Epilepsia à o mais freqÃente distÃrbio neurolÃgico, atingindo 50 milhÃes de pessoas no mundo, 40 milhÃes delas em paÃses desenvolvidos. Pessoas de todas as raÃas, sexos, condiÃÃes socioeconÃmicas e regiÃes sÃo acometidas. A pilocarpina (P400) à um agonista colinÃrgico que se caracteriza por induzir convulsÃes que evoluem para status epilÃpticus, similar à epilepsia do lobo temporal humana. O pentilenotetrazol (PTZ) à um antagonista GABA que mimetiza convulsÃes do pequeno-mal (crise de ausÃncia) e do tipo tÃnico-clÃnico em humanos. A estricnina à um potente convulsivante e atua, principalmente, como antagonista competitivo seletivo da inibiÃÃo pÃs-sinÃptica mediada pela glicina. Sua principal aÃÃo à o aumento da excitabilidade reflexa da medula. A picrotoxina à um agente convulsivante que bloqueia os canais de cloro ativados pelo Ãcido gama-aminobutÃrico. Os agentes convulsivantes foram administrados intraperitonialmente, apÃs 10 minutos da administraÃÃo intravenosa dos carbapenÃmcios Com o desenvolvimento deste trabalho, podemos observar que o prÃ-tratamento com imipenem ou meropenem interfere com vÃrios sistemas de neurotransmissores quando os animais sÃo submetidos à convulsÃo induzida pela pilocarpina na dose de 400mg/kg, pentilenotetrazol na dose de 55mg/Kg, estricnina 2mg/Kg e picrotoxina 10mg/Kg. Tal efeito foi evidenciado atravÃs do aumento nos nÃveis de aminoÃcidos excitatÃrios como o glutamato e, por outro lado, uma diminuiÃÃo nos nÃveis de aminoÃcidos inibitÃrios como o GABA reforÃando a existÃncia de uma possÃvel via modulatÃria desses aminoÃcidos no controle e desenvolvimento de crises epilÃpticas quando ocorre o prÃ-tratamento com imipenem/cilastatina ou meropenem. 2011-12-28 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9563 por info:eu-repo/semantics/openAccess application/pdf Universidade Federal do Cearà Programa de PÃs-GraduaÃÃo em Farmacologia UFC BR reponame:Biblioteca Digital de Teses e Dissertações da UFC instname:Universidade Federal do Ceará instacron:UFC |