The role of caspase-2 in the progression of Huntington disease in the YAC128 mouse
Huntington Disease (HD) is a neurodegenerative disorder caused by expansion of a poly-glutamine tract in the huntingtin (htt) protein. Poly-glutamine (polyQ) expansion of huntingtin leads to inevitable onset of affective, cognitive, motor symptoms and eventual death. Loss of neurons in specific regi...
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| Language: | English |
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University of British Columbia
2010
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| Online Access: | http://hdl.handle.net/2429/27744 |