The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice
This thesis explored the effects of cooked whole asparagus and its purified bioactive, rutin, on colitis symptoms and disease progression in mice using a chemically-induced model of colitis. This model mimics active colitis and recovery states of ulcerative colitis. C57BL/6 mice were fed a basal die...
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ndltd-LACETR-oai-collectionscanada.gc.ca-OGU.10214-53302013-10-04T04:14:28ZThe Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 MiceLu, Jenifer ThiUlcerative colitisInflammatory bowel diseaseInflammationAsparagusHealthDietAntioxidantPhenolicRutinQuercetinThis thesis explored the effects of cooked whole asparagus and its purified bioactive, rutin, on colitis symptoms and disease progression in mice using a chemically-induced model of colitis. This model mimics active colitis and recovery states of ulcerative colitis. C57BL/6 mice were fed a basal diet supplemented with 2% asparagus or 0.025% rutin for 3 weeks. Colitis was induced by 2% dextran sodium sulfate in drinking water for 7 days. Asparagus diet was determined to contain higher antioxidant capacities than rutin diet through antioxidant assays. During active colitis, consumption of asparagus alleviated some clinical symptoms (stool consistency, stool blood, and spleen hypertrophy) of colitis. In recovery, asparagus-fed mice were improving in terms of regenerating crypts, surface epithelial, and goblet cells, potentially due to its rutin content. Overall, these findings advocate that asparagus can be therapeutic in treating symptoms during active colitis and recovery phases of ulcerative colitis.Lindsay, Robinson2013-01-142013-01-17T19:26:48Z2013-05-01T05:00:20Z2013-01-17Thesishttp://hdl.handle.net/10214/5330en |
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Ulcerative colitis Inflammatory bowel disease Inflammation Asparagus Health Diet Antioxidant Phenolic Rutin Quercetin |
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Ulcerative colitis Inflammatory bowel disease Inflammation Asparagus Health Diet Antioxidant Phenolic Rutin Quercetin Lu, Jenifer Thi The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice |
description |
This thesis explored the effects of cooked whole asparagus and its purified bioactive, rutin, on colitis symptoms and disease progression in mice using a chemically-induced model of colitis. This model mimics active colitis and recovery states of ulcerative colitis. C57BL/6 mice were fed a basal diet supplemented with 2% asparagus or 0.025% rutin for 3 weeks. Colitis was induced by 2% dextran sodium sulfate in drinking water for 7 days. Asparagus diet was determined to contain higher antioxidant capacities than rutin diet through antioxidant assays. During active colitis, consumption of asparagus alleviated some clinical symptoms (stool consistency, stool blood, and spleen hypertrophy) of colitis. In recovery, asparagus-fed mice were improving in terms of regenerating crypts, surface epithelial, and goblet cells, potentially due to its rutin content. Overall, these findings advocate that asparagus can be therapeutic in treating symptoms during active colitis and recovery phases of ulcerative colitis. |
author2 |
Lindsay, Robinson |
author_facet |
Lindsay, Robinson Lu, Jenifer Thi |
author |
Lu, Jenifer Thi |
author_sort |
Lu, Jenifer Thi |
title |
The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice |
title_short |
The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice |
title_full |
The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice |
title_fullStr |
The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice |
title_full_unstemmed |
The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice |
title_sort |
effects of cooked whole asparagus (asparagus officinalis l.) and its purified bioactive, rutin, on symptoms of dss-induced acute colitis and recovery in c57bl/6 mice |
publishDate |
2013 |
url |
http://hdl.handle.net/10214/5330 |
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