GENOMIC CHARACTERIZATION OF RECURRENT CHROMOSOMAL ABERRATIONS IN RETINOBLASTOMA
Retinoblastoma is the second most common childhood intraocular malignancy and development of the tumour is initiated by bi-allelic loss of the RB1 gene. Bi-allelic RB1 loss may not always directly lead to malignant retinoblastoma. Subsequent mutational events, specifically gain and loss of chromoso...
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| Language: | en en |
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2010
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| Online Access: | http://hdl.handle.net/1974/6136 |