Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy

Ankylosing spondylitis (AS) is a chronic, inflammatory rheumatic disease that has a highly variable disease course. Three biologic agents, adalimumab, etanercept, and infliximab, have been developed for the treatment of AS. We conducted three studies: 1) an exploratory analysis of a year-long longit...

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Main Author: Maxwell, Lara J
Language:en
Published: 2011
Subjects:
Online Access:http://hdl.handle.net/10393/20093
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spelling ndltd-LACETR-oai-collectionscanada.gc.ca-OOU-OLD.-200932013-04-05T03:20:43ZAssessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF TherapyMaxwell, Lara Jankylosing spondylitisanti-TNF therapysystematic reviewlongitudinal analysisvariabilityAnkylosing spondylitis (AS) is a chronic, inflammatory rheumatic disease that has a highly variable disease course. Three biologic agents, adalimumab, etanercept, and infliximab, have been developed for the treatment of AS. We conducted three studies: 1) an exploratory analysis of a year-long longitudinal dataset to gain insight into the variability of disease activity, physical function, and well-being and to explore the relationship between these outcome measures; 2) a systematic review of the available evidence for the efficacy of biologic treatment; 3) a systematic review of potential adverse effects of this treatment. We found that repeated measures of disease activity, function and well-being fluctuate considerably between patients, with complex patterns occurring over time within patients. There was mostly high quality evidence that these biologics are efficacious against placebo. We did not find evidence of an increase in serious adverse events or serious infections from short-term randomized controlled trials.2011-07-05T17:22:46Z2012-07-05T07:00:09Z20112011-07-05Thèse / Thesishttp://hdl.handle.net/10393/20093en
collection NDLTD
language en
sources NDLTD
topic ankylosing spondylitis
anti-TNF therapy
systematic review
longitudinal analysis
variability
spellingShingle ankylosing spondylitis
anti-TNF therapy
systematic review
longitudinal analysis
variability
Maxwell, Lara J
Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy
description Ankylosing spondylitis (AS) is a chronic, inflammatory rheumatic disease that has a highly variable disease course. Three biologic agents, adalimumab, etanercept, and infliximab, have been developed for the treatment of AS. We conducted three studies: 1) an exploratory analysis of a year-long longitudinal dataset to gain insight into the variability of disease activity, physical function, and well-being and to explore the relationship between these outcome measures; 2) a systematic review of the available evidence for the efficacy of biologic treatment; 3) a systematic review of potential adverse effects of this treatment. We found that repeated measures of disease activity, function and well-being fluctuate considerably between patients, with complex patterns occurring over time within patients. There was mostly high quality evidence that these biologics are efficacious against placebo. We did not find evidence of an increase in serious adverse events or serious infections from short-term randomized controlled trials.
author Maxwell, Lara J
author_facet Maxwell, Lara J
author_sort Maxwell, Lara J
title Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy
title_short Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy
title_full Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy
title_fullStr Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy
title_full_unstemmed Assessment of Intra- and Inter-individual Variability of Outcome Measures in Ankylosing Spondylitis and the Efficacy and Adverse Effects of Anti-TNF Therapy
title_sort assessment of intra- and inter-individual variability of outcome measures in ankylosing spondylitis and the efficacy and adverse effects of anti-tnf therapy
publishDate 2011
url http://hdl.handle.net/10393/20093
work_keys_str_mv AT maxwelllaraj assessmentofintraandinterindividualvariabilityofoutcomemeasuresinankylosingspondylitisandtheefficacyandadverseeffectsofantitnftherapy
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