The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development
Cellular Inhibitor of Apoptosis 2 (cIAP2) belongs to the IAP family, a group of endogenous proteins that inhibit apoptosis. However, the physiological role of cIAP2 remains poorly defined. Knock-out (KO) and wild type (WT) mice were used to examine the effect of cIAP2 protein on the progression of a...
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ndltd-LACETR-oai-collectionscanada.gc.ca-OOU.-en#10393-202262013-01-11T13:33:11ZThe Role of cIAP2 in Early and Late Atherosclerosis Lesion DevelopmentSleiman, LyneAtherosclerosisApoptosisApoEMacrophageCellular Inhibitor of Apoptosis 2 (cIAP2) belongs to the IAP family, a group of endogenous proteins that inhibit apoptosis. However, the physiological role of cIAP2 remains poorly defined. Knock-out (KO) and wild type (WT) mice were used to examine the effect of cIAP2 protein on the progression of atherosclerosis in apoE -/- mice. Following the high-fat diet period of 4 and 12 wks, tissues were harvested and analysis focused on the aortic root, the aortic arch, the descending aorta, and the blood. Ex vivo results show a significant decrease in aortic arch lesion area in KO vs. WT in both study groups. Results also show a decrease in aortic root lesion size in KO vs. WT in both study groups. These results support that cIAP2 is an important survival factor for lesion-associated macrophages, since loss of cIAP2 expression in this mouse model reduced atherosclerotic lesion development.2011-09-22T14:46:11Z2011-09-22T14:46:11Z20112011-09-22http://hdl.handle.net/10393/20226en |
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en |
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Atherosclerosis Apoptosis ApoE Macrophage |
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Atherosclerosis Apoptosis ApoE Macrophage Sleiman, Lyne The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development |
description |
Cellular Inhibitor of Apoptosis 2 (cIAP2) belongs to the IAP family, a group of endogenous proteins that inhibit apoptosis. However, the physiological role of cIAP2 remains poorly defined. Knock-out (KO) and wild type (WT) mice were used to examine the effect of cIAP2 protein on the progression of atherosclerosis in apoE -/- mice. Following the high-fat diet period of 4 and 12 wks, tissues were harvested and analysis focused on the aortic root, the aortic arch, the descending aorta, and the blood. Ex vivo results show a significant decrease in aortic arch lesion area in KO vs. WT in both study groups. Results also show a decrease in aortic root lesion size in KO vs. WT in both study groups. These results support that cIAP2 is an important survival factor for lesion-associated macrophages, since loss of cIAP2 expression in this mouse model reduced atherosclerotic lesion development. |
author |
Sleiman, Lyne |
author_facet |
Sleiman, Lyne |
author_sort |
Sleiman, Lyne |
title |
The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development |
title_short |
The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development |
title_full |
The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development |
title_fullStr |
The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development |
title_full_unstemmed |
The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development |
title_sort |
role of ciap2 in early and late atherosclerosis lesion development |
publishDate |
2011 |
url |
http://hdl.handle.net/10393/20226 |
work_keys_str_mv |
AT sleimanlyne theroleofciap2inearlyandlateatherosclerosislesiondevelopment AT sleimanlyne roleofciap2inearlyandlateatherosclerosislesiondevelopment |
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1716575482067025920 |