The Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like Behaviours
Neurabin, a cytoskeletal protein, has been shown to be required for normal dopamine signalling, and dopaminergic systems have been previously implicated in the pathophysiology of anxiety disorders, including generalized social anxiety disorder. And results from neuroimaging studies have implicated...
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ndltd-LACETR-oai-collectionscanada.gc.ca-OTU.1807-245902013-04-20T05:21:23ZThe Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like BehavioursKim, Susan S.anterior cingulate cortexneurabinanxietydepressionsiRNAmicroinjection0317Neurabin, a cytoskeletal protein, has been shown to be required for normal dopamine signalling, and dopaminergic systems have been previously implicated in the pathophysiology of anxiety disorders, including generalized social anxiety disorder. And results from neuroimaging studies have implicated the anterior cingulate cortex (ACC) in depression and anxiety disorders. However, lesion studies have failed to produce the expected deficits. Here, we demonstrate that the injections of muscimol and midazolam into the ACC reduced anxiety- and depression-like behaviours, and that complete absence of neurabin reduced anxiety-like behaviour but increased depression-like behaviour. However, reduction of neurabin by injecting neurabin-targeted siRNA into the ACC reduced anxiety-like behaviour but did not affect depression-like behaviour. This study provides evidence that the imbalance of excitatory and inhibitory activity in the ACC alters affective disorders, and that neurabin may be critical for the modulation of these behaviours.Zhuo, Min2010-062010-07-27T15:37:28ZNO_RESTRICTION2010-07-27T15:37:28Z2010-07-27T15:37:28ZThesishttp://hdl.handle.net/1807/24590en_ca |
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anterior cingulate cortex neurabin anxiety depression siRNA microinjection 0317 |
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anterior cingulate cortex neurabin anxiety depression siRNA microinjection 0317 Kim, Susan S. The Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like Behaviours |
description |
Neurabin, a cytoskeletal protein, has been shown to be required for normal dopamine signalling, and dopaminergic systems have been previously implicated in the pathophysiology of anxiety disorders, including generalized social anxiety disorder. And results from neuroimaging studies have implicated the anterior cingulate cortex (ACC) in depression and anxiety disorders. However, lesion studies have failed to produce the expected deficits. Here, we demonstrate that the injections of muscimol and midazolam into the ACC reduced anxiety- and depression-like behaviours, and that complete absence of neurabin reduced anxiety-like behaviour but increased depression-like behaviour. However, reduction of neurabin by injecting neurabin-targeted siRNA into the ACC reduced anxiety-like behaviour but did not affect depression-like behaviour. This study provides evidence that the imbalance of excitatory and inhibitory activity in the ACC alters affective disorders, and that neurabin may be critical for the modulation of these behaviours. |
author2 |
Zhuo, Min |
author_facet |
Zhuo, Min Kim, Susan S. |
author |
Kim, Susan S. |
author_sort |
Kim, Susan S. |
title |
The Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like Behaviours |
title_short |
The Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like Behaviours |
title_full |
The Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like Behaviours |
title_fullStr |
The Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like Behaviours |
title_full_unstemmed |
The Role of the Anterior Cingulate Cortex and Neurabin in Anxiety- and Depression-like Behaviours |
title_sort |
role of the anterior cingulate cortex and neurabin in anxiety- and depression-like behaviours |
publishDate |
2010 |
url |
http://hdl.handle.net/1807/24590 |
work_keys_str_mv |
AT kimsusans theroleoftheanteriorcingulatecortexandneurabininanxietyanddepressionlikebehaviours AT kimsusans roleoftheanteriorcingulatecortexandneurabininanxietyanddepressionlikebehaviours |
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1716583413012496384 |