Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma
Cryoprecipitate is commonly used outside guidelines. In trauma, the appropriate cryoprecipitate dose and its impact on plasma fibrinogen levels are unclear. This retrospective study aims to evaluate: (1) the appropriateness of cryoprecipitate transfusion in trauma; and (2) the plasma fibrinogen res...
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ndltd-LACETR-oai-collectionscanada.gc.ca-OTU.1807-326112013-11-05T03:40:56ZCryoprecipitate Transfusion: Assessing Appropriateness and Dosing in TraumaNascimento, Bartolomeu Jr.Cryoprecipitate transfusionappropriatenessdosingtrauma0564Cryoprecipitate is commonly used outside guidelines. In trauma, the appropriate cryoprecipitate dose and its impact on plasma fibrinogen levels are unclear. This retrospective study aims to evaluate: (1) the appropriateness of cryoprecipitate transfusion in trauma; and (2) the plasma fibrinogen response to cryoprecipitate transfusion during massive transfusion in trauma. Fibrinogen levels of < 1.0 g/L within 2 and 6 hours of cryoprecipitate transfusion were used for assessing appropriateness. Out of 394 events, 238 (60%) and 259 (66%) were considered appropriate using 2 and 6 hour criteria, respectively. A dose of 8.7 (±1.7) units caused a mean increase in fibrinogen levels of 0.55 (±0.24) g/L, or 0.06g/L per unit. In our hospital, where transfusion guidelines and policies for rapid blood product and laboratory turnaround times exist, it is possible to achieve high rates of appropriateness for cryoprecipitate transfusion in trauma. The current recommended dose causes a modest increase in fibrinogen levels.Rizoli, Sandro Baleotti2012-062012-08-15T18:11:21ZNO_RESTRICTION2012-08-15T18:11:21Z2012-08-15Thesishttp://hdl.handle.net/1807/32611en_ca |
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en_ca |
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Cryoprecipitate transfusion appropriateness dosing trauma 0564 |
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Cryoprecipitate transfusion appropriateness dosing trauma 0564 Nascimento, Bartolomeu Jr. Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma |
description |
Cryoprecipitate is commonly used outside guidelines. In trauma, the appropriate cryoprecipitate dose and its impact on plasma fibrinogen levels are unclear.
This retrospective study aims to evaluate: (1) the appropriateness of cryoprecipitate transfusion in trauma; and (2) the plasma fibrinogen response to cryoprecipitate transfusion during massive transfusion in trauma.
Fibrinogen levels of < 1.0 g/L within 2 and 6 hours of cryoprecipitate transfusion were used for assessing appropriateness. Out of 394 events, 238 (60%) and 259 (66%) were considered appropriate using 2 and 6 hour criteria, respectively. A dose of 8.7 (±1.7) units caused a mean increase in fibrinogen levels of 0.55 (±0.24) g/L, or 0.06g/L per unit.
In our hospital, where transfusion guidelines and policies for rapid blood product and laboratory turnaround times exist, it is possible to achieve high rates of appropriateness for cryoprecipitate transfusion in trauma. The current recommended dose causes a modest increase in fibrinogen levels. |
author2 |
Rizoli, Sandro Baleotti |
author_facet |
Rizoli, Sandro Baleotti Nascimento, Bartolomeu Jr. |
author |
Nascimento, Bartolomeu Jr. |
author_sort |
Nascimento, Bartolomeu Jr. |
title |
Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma |
title_short |
Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma |
title_full |
Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma |
title_fullStr |
Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma |
title_full_unstemmed |
Cryoprecipitate Transfusion: Assessing Appropriateness and Dosing in Trauma |
title_sort |
cryoprecipitate transfusion: assessing appropriateness and dosing in trauma |
publishDate |
2012 |
url |
http://hdl.handle.net/1807/32611 |
work_keys_str_mv |
AT nascimentobartolomeujr cryoprecipitatetransfusionassessingappropriatenessanddosingintrauma |
_version_ |
1716612891717664768 |