Some aspects of the nature of chloramphenicol resistance in salmonella.

• Main Author: Gill, Peter.
• Other Authors: Stevenson, J. (Supervisor)
• Format: Others
• Language: en
• Published: McGill University 1964
• Subjects: Bacteriology and Immunology.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115503

Previous work in this department by the present author and others, has demonstrated that changes accompanying the acquisition of resistance to chloramphenicol in Salmonella indicate structural changes in the surface of resistant organisms. Similar changes have been reported by other workers investigating both gram-positive and gram-negative chloramphenicol resistant organisms. The additional observation of a simultaneous increase in resistance to other antibiotics such as penicillin implies a possible non-specific mechanism contributing to resistance linked to the relative permeabilities of the cells. Work was therefore continued with a resistant strain of Salmonella typhimurium in an attempt to find out more about the mechanism of resistance.