Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation

Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation

The activation of the protein tyrosine kinase (PTK) ZAP-70 is fundamental to T cell receptor (TCR) signal transduction. TCR engagement induces raft-association of ZAP-70 and juxtaposes the cytoplasmic ZAP-70 with the raft-enriched Lck, which phosphorylates and activates ZAP-70. The active ZAP-70, co...

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Bibliographic Details
Main Author: Yang, Yaoming
Format: Others
Language:en
Published: McGill University 2003
Subjects:
Protein-Tyrosine Kinases.
Phosphatidylserines
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19442
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spelling ndltd-LACETR-oai-collectionscanada.gc.ca-QMM.194422014-02-13T03:53:32ZRegulation of protein tyrosine kinase ZAP-70 by serine phosphorylationYang, YaomingProtein-Tyrosine Kinases.PhosphatidylserinesThe activation of the protein tyrosine kinase (PTK) ZAP-70 is fundamental to T cell receptor (TCR) signal transduction. TCR engagement induces raft-association of ZAP-70 and juxtaposes the cytoplasmic ZAP-70 with the raft-enriched Lck, which phosphorylates and activates ZAP-70. The active ZAP-70, cooperatively with Lck, initiates multiple intracellular pathways eventually leading to T cell activation and IL-2 production. Here, we describe the serine phosphorylation on ZAP-70 on the highly conserved S520DVWS524 motif, and investigate its role in coupling ZAP-70 with TCR signal transduction.McGill University2003Electronic Thesis or Dissertationapplication/pdfenalephsysno: 002010389Theses scanned by McGill Library.All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.Doctor of Philosophy (Division of Experimental Medicine) http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19442
collection NDLTD
language en
format Others
sources NDLTD
topic Protein-Tyrosine Kinases.
Phosphatidylserines
spellingShingle Protein-Tyrosine Kinases.
Phosphatidylserines
Yang, Yaoming
Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation
description The activation of the protein tyrosine kinase (PTK) ZAP-70 is fundamental to T cell receptor (TCR) signal transduction. TCR engagement induces raft-association of ZAP-70 and juxtaposes the cytoplasmic ZAP-70 with the raft-enriched Lck, which phosphorylates and activates ZAP-70. The active ZAP-70, cooperatively with Lck, initiates multiple intracellular pathways eventually leading to T cell activation and IL-2 production. Here, we describe the serine phosphorylation on ZAP-70 on the highly conserved S520DVWS524 motif, and investigate its role in coupling ZAP-70 with TCR signal transduction.
author Yang, Yaoming
author_facet Yang, Yaoming
author_sort Yang, Yaoming
title Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation
title_short Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation
title_full Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation
title_fullStr Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation
title_full_unstemmed Regulation of protein tyrosine kinase ZAP-70 by serine phosphorylation
title_sort regulation of protein tyrosine kinase zap-70 by serine phosphorylation
publisher McGill University
publishDate 2003
url http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19442
work_keys_str_mv AT yangyaoming regulationofproteintyrosinekinasezap70byserinephosphorylation
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