The effect of fatty acid composition of plant sterol esters on blood lipid profiles and plasma plant sterol levels in hypercholesterolemic subjects /

• Main Author: Chan, Yen-Ming, 1980-
• Format: Others
• Language: en
• Published: McGill University 2006
• Subjects: Sterols > Physiological effect.; Blood lipids.; Hypercholesteremia > Treatment.; Phytosterols.
• Online Access: http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97923

To evaluate the relative efficacy of plant sterols (PS) esterified with the fatty acids from fish oil (PS-FO), olive oil (PS-OO) and sunflower oil (PS-SO) on blood lipid and PS concentrations, 21 hyperlipidemic subjects were randomly assigned to each of five treatments for 28 days using a cross-over design. The results showed that: (1) in a comparison of olive oil (OO), fish oil (FO), PS-FO and PS-SO subgroup, PS-FO reduced triacylglycerols (TG) relative to PS-SO. Total cholesterol (T-C)/high-density lipoprotein cholesterol (HDL-C) ratio was reduced with PS-FO compared with FO. Plasma PS levels were increased with PS-SO and PS-FO. (2) in a comparison of OO, PS-SO and PS-OO subgroup, PS-OO had a larger decrease in T-C than OO, while PS-SO and OO reduced T-C equally. Both PS-SO and PS-OO elevated plasma PS levels. Overall, PS-FO and PS-OO have a higher potential for decreasing the risk of cardiovascular disease in hyperlipidemic subjects than PS-SO and OO supplementations.