Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2017. === Cataloged from PDF version of thesis. === Includes bibliographical references (pages 158-177). === Huntington's disease (HD), the most common inherited neurodegenerative disorder, is cau...
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ndltd-MIT-oai-dspace.mit.edu-1721.1-1139472019-05-02T15:55:23Z Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2 Hachigian, Lea June Myriam Heiman. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Brain and Cognitive Sciences. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2017. Cataloged from PDF version of thesis. Includes bibliographical references (pages 158-177). Huntington's disease (HD), the most common inherited neurodegenerative disorder, is caused by mutations in the huntingtin (HTT) gene, which encodes a poly-glutamine (polyQ) repeat protein. Despite widespread expression of the HTT gene, HD presents with massive neuronal cell loss and transcriptional dysregulation primarily in the striatum and deep layers of the cortex. Synaptic dysfunction and motor deficits are also prominent in HD patients as well as mouse models. In an attempt to identify factors that could both explain these alterations and mirror these vulnerability patterns, we identified a potential role for the striatal-enriched polyQ protein Foxp2 in HD. The transcription factor Foxp2 was recently identified as a crucial regulator of striatal synaptogenesis and corticostriatal inputs during striatal development, and has also been demonstrated to play a critical role in motor learning. Here we show that, in mice, overexpression of Foxp2 in the adult striatum of two models of HD leads to rescue of HD-associated behaviors, while knockdown of Foxp2 in wild-type adult striatum leads to development of HD-associated behaviors. We note that Foxp2 encodes the longest polyglutamine repeat protein in the human reference genome, and we show that it can be sequestered into aggregates with polyglutamine-expanded mutant HTT protein. Foxp2 overexpression in HD model mice leads to altered expression of several genes associated with synaptic function, genes which present new targets for normalization of corticostriatal dysfunction in HD. by Lea June Hachigian. Ph. D. 2018-03-02T22:20:06Z 2018-03-02T22:20:06Z 2017 2017 Thesis http://hdl.handle.net/1721.1/113947 1023434078 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 177 pages application/pdf Massachusetts Institute of Technology |
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Brain and Cognitive Sciences. Hachigian, Lea June Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2 |
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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2017. === Cataloged from PDF version of thesis. === Includes bibliographical references (pages 158-177). === Huntington's disease (HD), the most common inherited neurodegenerative disorder, is caused by mutations in the huntingtin (HTT) gene, which encodes a poly-glutamine (polyQ) repeat protein. Despite widespread expression of the HTT gene, HD presents with massive neuronal cell loss and transcriptional dysregulation primarily in the striatum and deep layers of the cortex. Synaptic dysfunction and motor deficits are also prominent in HD patients as well as mouse models. In an attempt to identify factors that could both explain these alterations and mirror these vulnerability patterns, we identified a potential role for the striatal-enriched polyQ protein Foxp2 in HD. The transcription factor Foxp2 was recently identified as a crucial regulator of striatal synaptogenesis and corticostriatal inputs during striatal development, and has also been demonstrated to play a critical role in motor learning. Here we show that, in mice, overexpression of Foxp2 in the adult striatum of two models of HD leads to rescue of HD-associated behaviors, while knockdown of Foxp2 in wild-type adult striatum leads to development of HD-associated behaviors. We note that Foxp2 encodes the longest polyglutamine repeat protein in the human reference genome, and we show that it can be sequestered into aggregates with polyglutamine-expanded mutant HTT protein. Foxp2 overexpression in HD model mice leads to altered expression of several genes associated with synaptic function, genes which present new targets for normalization of corticostriatal dysfunction in HD. === by Lea June Hachigian. === Ph. D. |
author2 |
Myriam Heiman. |
author_facet |
Myriam Heiman. Hachigian, Lea June |
author |
Hachigian, Lea June |
author_sort |
Hachigian, Lea June |
title |
Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2 |
title_short |
Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2 |
title_full |
Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2 |
title_fullStr |
Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2 |
title_full_unstemmed |
Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2 |
title_sort |
modulation of huntington's disease-associated phenotypes by the striatal-enriched transcription factor foxp2 |
publisher |
Massachusetts Institute of Technology |
publishDate |
2018 |
url |
http://hdl.handle.net/1721.1/113947 |
work_keys_str_mv |
AT hachigianleajune modulationofhuntingtonsdiseaseassociatedphenotypesbythestriatalenrichedtranscriptionfactorfoxp2 |
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