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ndltd-NEU--neu-cj82qq2012021-04-13T05:13:43ZSpecificity of damage-bypass DNA polymerases E. coli DinB and human pol κDNA damage is a constant threat and can block replication. Y-family DNA polymerases can replicate damaged DNA through the process of translesion synthesis (TLS). Y-family DNA polymerases are conserved in all domains of life and bypass specific DNA damage in either an error-free or error-prone manner. This dissertation presents work to understand the damage specificity and nucleotide incorporation specificity of Y-family DNA polymerase orthologs E. coli DinB and human pol κ.http://hdl.handle.net/2047/D20260514
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DNA damage is a constant threat and can block replication. Y-family DNA polymerases can replicate damaged DNA through the process of translesion synthesis (TLS). Y-family DNA polymerases are conserved in all domains of life and bypass specific DNA damage in either an error-free or error-prone manner. This dissertation presents work to understand the damage specificity and nucleotide incorporation specificity of Y-family DNA polymerase orthologs E. coli DinB and human pol κ.
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Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
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| spellingShingle |
Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
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| title_short |
Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
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| title_full |
Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
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| title_fullStr |
Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
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| title_full_unstemmed |
Specificity of damage-bypass DNA polymerases E. coli DinB and human pol κ
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| title_sort |
specificity of damage-bypass dna polymerases e. coli dinb and human pol κ
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http://hdl.handle.net/2047/D20260514
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1719395649951105024
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