Intranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammation

Neurodegenerative diseases are the most prevalent brain diseases affecting more than 5.5 million people worldwide. If left unconstrained, 30 years from now, more than 12 million Americans will suffer from these diseases. neuro-inflammation has been one of the common denominator in broad spectrum of...

Full description

Bibliographic Details
Published:
Online Access:http://hdl.handle.net/2047/D20198907
id ndltd-NEU--neu-rx9181521
record_format oai_dc
spelling ndltd-NEU--neu-rx91815212021-05-28T05:22:26ZIntranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammationNeurodegenerative diseases are the most prevalent brain diseases affecting more than 5.5 million people worldwide. If left unconstrained, 30 years from now, more than 12 million Americans will suffer from these diseases. neuro-inflammation has been one of the common denominator in broad spectrum of neurodegenerative diseases, such as Alzheimer's, Parkinson's, Sclerosis, and age-related macular degeneration diseases. Prevention and cure of these brain diseases has been facing outstanding challenge due the limited delivery of pharmacological therapeutics to the brain primarily due to presence of blood-brain barrier (BBB), blood-CSF barrier and expression of efflux transporters.http://hdl.handle.net/2047/D20198907
collection NDLTD
sources NDLTD
description Neurodegenerative diseases are the most prevalent brain diseases affecting more than 5.5 million people worldwide. If left unconstrained, 30 years from now, more than 12 million Americans will suffer from these diseases. neuro-inflammation has been one of the common denominator in broad spectrum of neurodegenerative diseases, such as Alzheimer's, Parkinson's, Sclerosis, and age-related macular degeneration diseases. Prevention and cure of these brain diseases has been facing outstanding challenge due the limited delivery of pharmacological therapeutics to the brain primarily due to presence of blood-brain barrier (BBB), blood-CSF barrier and expression of efflux transporters.
title Intranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammation
spellingShingle Intranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammation
title_short Intranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammation
title_full Intranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammation
title_fullStr Intranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammation
title_full_unstemmed Intranasal delivery for peptide and siRNA to the brain using lipid-based nanocarriers for the treatment of neuroinflammation
title_sort intranasal delivery for peptide and sirna to the brain using lipid-based nanocarriers for the treatment of neuroinflammation
publishDate
url http://hdl.handle.net/2047/D20198907
_version_ 1719408008797093888