Reduced intraabdominal fat after lower-dose treadmill training in growing female rats

The presence of an increased accumulation of intraabdominal fat (IAF) has been linked to dyslipidemia, hyperinsulinemia, and hyperglycemia, which precede the development of type 2 diabetes and coronary artery disease (CAD). It has been shown that IAF begins depostition during childhood. Human studie...

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Main Author: David, Lynne Catherine
Other Authors: Williams, Daniel P.
Language:en_US
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/1957/30988
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spelling ndltd-ORGSU-oai-ir.library.oregonstate.edu-1957-309882012-07-13T03:16:40ZReduced intraabdominal fat after lower-dose treadmill training in growing female ratsDavid, Lynne CatherineRats -- Exercise -- Physiological aspectsExercise -- Physiological aspectsThe presence of an increased accumulation of intraabdominal fat (IAF) has been linked to dyslipidemia, hyperinsulinemia, and hyperglycemia, which precede the development of type 2 diabetes and coronary artery disease (CAD). It has been shown that IAF begins depostition during childhood. Human studies suggest that regular endurance exercise, that does not necessarily produce an increase in aerobic capacity, can effectively reduce IAF accumulation during these early years. In contrast to human research, studies using animal models of human disease typically employ extremely large volumes of exercise with the intent to maximize aerobic capacity. The present study examined whether half the amount of endurance training, that was previously reported to induce cardiac hypertrophy and approximately double the aerobic capacity of skeletal muscle in rats, would reduce the growth-related accumulation of IAF in growing female rats. Twenty-two 4-week-old female Sprague-Dawley rats were randomly assigned to a running experimental or a non-running control group. The runners exercised on a treadmill 5 days/week for 60 min/day at a speed of 27m/min and up a 15% grade for 10 weeks. After 10 weeks, the parametrial, omental and mesenteric IAF depots and the heart were excised and weighed. Compared with non-runners, the runners had a significantly lower mean parametrial fat mass (2.22 g vs. 3.13 g, p=0.05) and a higher mean heart weight (0.97 g vs. 0.90 g, p=0.05) at the end of 10 weeks. In addition, the lower mean parametrial fat mass in the runners vs. the non-runners (2.19 g vs. 3.19 g, p=0.02) remained significant even after adjusting for the greater heart weights of the runners. One-half the amount of exercise, that was previously reported to induce cardiac hypertrophy and approximately double the aerobic capacity of skeletal muscle in rats, yielded an 8% greater heart weight and a 29% lower parametrial IAF mass, on average, in growing female rats. In addition, the effects of treadmill running on reducing parametrial fat accumulation were independent of the effects of running on increasing heart weight. Thus, future studies examining the effects of exercise on IAF and other health-related metabolic outcomes in rats may consider using lower-dose endurance training protocols that are not designed to maximize improvements in aerobic capacity.Graduation date: 2002Williams, Daniel P.2012-07-12T18:59:00Z2012-07-12T18:59:00Z2001-10-122001-10-12Thesis/Dissertationhttp://hdl.handle.net/1957/30988en_US
collection NDLTD
language en_US
sources NDLTD
topic Rats -- Exercise -- Physiological aspects
Exercise -- Physiological aspects
spellingShingle Rats -- Exercise -- Physiological aspects
Exercise -- Physiological aspects
David, Lynne Catherine
Reduced intraabdominal fat after lower-dose treadmill training in growing female rats
description The presence of an increased accumulation of intraabdominal fat (IAF) has been linked to dyslipidemia, hyperinsulinemia, and hyperglycemia, which precede the development of type 2 diabetes and coronary artery disease (CAD). It has been shown that IAF begins depostition during childhood. Human studies suggest that regular endurance exercise, that does not necessarily produce an increase in aerobic capacity, can effectively reduce IAF accumulation during these early years. In contrast to human research, studies using animal models of human disease typically employ extremely large volumes of exercise with the intent to maximize aerobic capacity. The present study examined whether half the amount of endurance training, that was previously reported to induce cardiac hypertrophy and approximately double the aerobic capacity of skeletal muscle in rats, would reduce the growth-related accumulation of IAF in growing female rats. Twenty-two 4-week-old female Sprague-Dawley rats were randomly assigned to a running experimental or a non-running control group. The runners exercised on a treadmill 5 days/week for 60 min/day at a speed of 27m/min and up a 15% grade for 10 weeks. After 10 weeks, the parametrial, omental and mesenteric IAF depots and the heart were excised and weighed. Compared with non-runners, the runners had a significantly lower mean parametrial fat mass (2.22 g vs. 3.13 g, p=0.05) and a higher mean heart weight (0.97 g vs. 0.90 g, p=0.05) at the end of 10 weeks. In addition, the lower mean parametrial fat mass in the runners vs. the non-runners (2.19 g vs. 3.19 g, p=0.02) remained significant even after adjusting for the greater heart weights of the runners. One-half the amount of exercise, that was previously reported to induce cardiac hypertrophy and approximately double the aerobic capacity of skeletal muscle in rats, yielded an 8% greater heart weight and a 29% lower parametrial IAF mass, on average, in growing female rats. In addition, the effects of treadmill running on reducing parametrial fat accumulation were independent of the effects of running on increasing heart weight. Thus, future studies examining the effects of exercise on IAF and other health-related metabolic outcomes in rats may consider using lower-dose endurance training protocols that are not designed to maximize improvements in aerobic capacity. === Graduation date: 2002
author2 Williams, Daniel P.
author_facet Williams, Daniel P.
David, Lynne Catherine
author David, Lynne Catherine
author_sort David, Lynne Catherine
title Reduced intraabdominal fat after lower-dose treadmill training in growing female rats
title_short Reduced intraabdominal fat after lower-dose treadmill training in growing female rats
title_full Reduced intraabdominal fat after lower-dose treadmill training in growing female rats
title_fullStr Reduced intraabdominal fat after lower-dose treadmill training in growing female rats
title_full_unstemmed Reduced intraabdominal fat after lower-dose treadmill training in growing female rats
title_sort reduced intraabdominal fat after lower-dose treadmill training in growing female rats
publishDate 2012
url http://hdl.handle.net/1957/30988
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