TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE

TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE

Bibliographic Details
Main Author: Komurcu, Ramazan
Language:English
Published: University of Akron / OhioLINK 2007
Subjects:
DENDRIMER
TRYPTAMINE
tetra acid
DCC
NMR
tryptamine conjugated
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=akron1196653318
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-akron11966533182021-08-03T05:25:17Z TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE Komurcu, Ramazan DENDRIMER TRYPTAMINE tetra acid DCC NMR tryptamine conjugated Polymer-based drug delivery is used to overcome poor drug water solubility and to deliver drugs more effectively and efficiently. It is also used to reduce the amount of the needed drug, to increase the half-life of drug, and to keep the drug level in a desirable range. One interesting polymer-based drug delivery method uses dendrimers as carriers, continuously releasing drugs into the human body. In this study, first generation of carboxylic acid–terminated four-directional Z-cascade: methane [4]: (3-oxo-6-oxa-2-azapentylidyne): propanoic acid and tryptamine were used as a dendrimer and a model drug, respectively. It is the first time this dendrimer and model drug were used in advanced drug delivery. Before coupling tryptamine to the dendrimer, the coupling strategy was examined with an aliphatic acid, heptanoic acid, and the dendrimer building block, tetra acid. The synthesis and characterization of the products were completed successfully and the yields for tryptamine conjugated heptanoic acid, tetra acid, and polyamide dendrimer were observed as 70%, 67%, and 53%, respectively. Then, in vitro enzymatic release study of tryptamine conjugated polyamide dendrimer was studied. Half of the drug was released within nine hours, demonstrating the concept of using this dendrimer for extended release. 2007 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1196653318 http://rave.ohiolink.edu/etdc/view?acc_num=akron1196653318 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic DENDRIMER
TRYPTAMINE
tetra acid
DCC
NMR
tryptamine conjugated
spellingShingle DENDRIMER
TRYPTAMINE
tetra acid
DCC
NMR
tryptamine conjugated
Komurcu, Ramazan
TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE
author Komurcu, Ramazan
author_facet Komurcu, Ramazan
author_sort Komurcu, Ramazan
title TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE
title_short TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE
title_full TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE
title_fullStr TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE
title_full_unstemmed TRYPTAMINE TERMINATED 1st GENERATION POLYAMIDE DENDRIMER:SYNTHESIS AND DRUG RELEASE
title_sort tryptamine terminated 1st generation polyamide dendrimer:synthesis and drug release
publisher University of Akron / OhioLINK
publishDate 2007
url http://rave.ohiolink.edu/etdc/view?acc_num=akron1196653318
work_keys_str_mv AT komurcuramazan tryptamineterminated1stgenerationpolyamidedendrimersynthesisanddrugrelease
_version_ 1719419649070727168

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