Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study

Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study

Bibliographic Details
Main Author: Goldsmith, Neil
Language:English
Published: Bowling Green State University / OhioLINK 2008
Subjects:
Biophysics
CALCIUM
diffusion
MUSCLE
SERCA pump
CONTRACTION
SARCOMERE
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1225672739
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-bgsu12256727392021-08-03T05:28:38Z Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study Goldsmith, Neil Biophysics CALCIUM diffusion MUSCLE SERCA pump CONTRACTION SARCOMERE The human body uses calcium as an activator for muscle contraction. A muscle contraction begins with the release of calcium from the terminal cisternae into the sarcomere. The interaction of calcium with myoplasmic proteins then causes the muscle to contract. A biophysical model of the sarcomere will be developed in order to use the model to connect chemical concentrations with force production by the muscle. Since the sarcomere is the base contractile unit of muscle, it should therefore be the appropriate starting point for such a model. The model includes calcium release, diffusion, binding, and uptake. Magnesium concentrations are also modeled as they compete for calcium binding sites on parvalbumin, ATP, and troponin. The binding of calcium to troponin is of special importance because it results in unblocking of the actin sites. The actin will then interact with myosin in a multi-step process that is well understood but poorly quantified. This interaction leads to contraction of the sarcomere and thus the production of force. 2008-12-01 English text Bowling Green State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1225672739 http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1225672739 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biophysics
CALCIUM
diffusion
MUSCLE
SERCA pump
CONTRACTION
SARCOMERE
spellingShingle Biophysics
CALCIUM
diffusion
MUSCLE
SERCA pump
CONTRACTION
SARCOMERE
Goldsmith, Neil
Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study
author Goldsmith, Neil
author_facet Goldsmith, Neil
author_sort Goldsmith, Neil
title Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study
title_short Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study
title_full Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study
title_fullStr Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study
title_full_unstemmed Calcium Movement in the Sarcomere and its Connection to Muscle Contraction: A Pilot Study
title_sort calcium movement in the sarcomere and its connection to muscle contraction: a pilot study
publisher Bowling Green State University / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1225672739
work_keys_str_mv AT goldsmithneil calciummovementinthesarcomereanditsconnectiontomusclecontractionapilotstudy
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