The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats

Bibliographic Details
Main Author:	Wang, Zhi
Language:	English
Published:	Bowling Green State University / OhioLINK 2011
Subjects:	PCB
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1322545333

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-bgsu13225453332021-08-03T05:29:51Z The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats Wang, Zhi PCB Polychlorinated biphenyls (PCBs) are a group of chemicals that has been widely known for their endocrine disrupting effects. Because of their commercial use in industries all over the world, they have found their way into the environment and remain a concern for the health of public. One of the major disrupting effects of PCBs is the disturbance of the reproduction system of mammals. To investigate the disruptive effect of a particular mixture, PCB 47/77, on young rats and also to elucidate the different disruptive effects caused by the differences of exposure stage in these developing animals, in the present study pregnant rats were fed diet containing the PCB47/77 mixture and their pups were cross-fostered to mothers not exposed to PCB and vice versa. Our result have shown that the PCB 47/77 treatment can induce disrupting effect on the reproductive system of their female pups, causing the prematuration of the ovaries and uterus as early as 17 days of age. The group of cross-foster pups exposed to PCB lactationally appears to suffer more greatly from various disruptive effects than those exposed gestationally, suggesting that the neonatal developmental stage could possibly be even more vulnerable than the gestational period of development. Since this trend is consistent with a significantly lower concentration of serum thyroid hormone than in the other cross-fostered group, it is likely that hypothyroidism plays a major role in the PCB disrupting effects. 2011-11-29 English text Bowling Green State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1322545333 http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1322545333 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	PCB
spellingShingle	PCB Wang, Zhi The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats
author	Wang, Zhi
author_facet	Wang, Zhi
author_sort	Wang, Zhi
title	The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats
title_short	The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats
title_full	The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats
title_fullStr	The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats
title_full_unstemmed	The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats
title_sort	effect of pcb 47 and pcb 77 on the female reproductive system: gestational versus lactational effects in rats
publisher	Bowling Green State University / OhioLINK
publishDate	2011
url	http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1322545333
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The Effect of PCB 47 and PCB 77 on the Female Reproductive System: Gestational Versus Lactational Effects in Rats

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