STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA

STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA

Bibliographic Details
Main Author: Ramakrishnan, Devi Prasadh
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2008
Subjects:
CIH
NPY
EFFLUX
ADRENAL
NPY-LI
NPY-LI efflux
HYPOXIA
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case12012024722021-08-03T05:32:35Z STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA Ramakrishnan, Devi Prasadh CIH NPY EFFLUX ADRENAL NPY-LI NPY-LI efflux HYPOXIA Chronic intermittent hypoxia (CIH) augments norepinephrine (NE) efflux to acute hypoxia in adult rat adrenal medulla (AM). Neuropeptide-Y (NPY) is shown to be co-stored with NE and facilitate its release from AM through NPY-Y1 receptor. This study examines if CIH alters NPY efflux from adult rat AM and, if so, by what mechanism(s), and the effect of NPY on CIH induced increase in blood pressure. NPY and NE effluxes were studied from ex vivo AM. Results of this study show that while acute hypoxia and acidic hypercapnia augments NPY efflux, isohydric hypercapnia and nicotine inhibited NPY efflux in CIH exposed AM. NPY, by facilitating NE efflux through NPY-Y1 receptor, contributes to CIH induced blood pressure raise. Antioxidant treatment restored the nicotine-evoked and inhibited acute hypoxia-evoked NPY efflux from AM of rats exposed to CIH suggesting mechanisms involving oxidant radicals are responsible for CIH induced alterations in NPY efflux. 2008-02-05 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472 http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic CIH
NPY
EFFLUX
ADRENAL
NPY-LI
NPY-LI efflux
HYPOXIA
spellingShingle CIH
NPY
EFFLUX
ADRENAL
NPY-LI
NPY-LI efflux
HYPOXIA
Ramakrishnan, Devi Prasadh
STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA
author Ramakrishnan, Devi Prasadh
author_facet Ramakrishnan, Devi Prasadh
author_sort Ramakrishnan, Devi Prasadh
title STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA
title_short STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA
title_full STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA
title_fullStr STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA
title_full_unstemmed STUDIES ON NEUROPEPTIDE-Y EFFLUX FROM ADULT RAT ADRENAL MEDULLA – EFFECT OF CHRONIC INTERMITTENT HYPOXIA
title_sort studies on neuropeptide-y efflux from adult rat adrenal medulla – effect of chronic intermittent hypoxia
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=case1201202472
work_keys_str_mv AT ramakrishnandeviprasadh studiesonneuropeptideyeffluxfromadultratadrenalmedullaeffectofchronicintermittenthypoxia
_version_ 1719421501028958208

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