SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY

Bibliographic Details
Main Author:	Guo, Ming
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2008
Subjects:	Chemistry Pc Si CH2 CH3 3NH HOSiPcOSi CH2Cl2
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case12064541972021-08-03T05:32:35Z SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY Guo, Ming Chemistry Pc Si CH2 CH3 3NH HOSiPcOSi CH2Cl2 <p>A series of Pc 4 related compounds consisting of OH-substituted derivatives, Pc 4 salts and Pc 4 OH-substituted derivative salts has been prepared. The salts have been synthesized by straightforward acid-base reactions. Solubility studies of the Pc 4, the OH-substituted derivatives, the Pc 4 salts and the OH-substituted derivative salts in representative organic solvents and in aqueous dispersant-containing solutions have been carried out. Different dosage forms of Pc 4 including a liquid salt, aqueous solutions, a mineral oil solution, gels, a cream, and water-swellable films have been formulated.</p><p> In addition, membrane penetration studies of the formulation of Pc 4 used in a completed Phase I clinical trial done at University Hospitals of Cleveland have been conducted. Polyurethane, cellulose, polyvinylidene fluoride, silicone, pig keratome, and human roof blister membranes have been used in the study.</p><p> In unrelated work, the known polymers, chrysotile-derived trimethylsiloxy scroll polymer, and chrysotile-derived vinyldimethylsiloxy scroll polymer have been made. Also, the new polymers chrysotile-derived trimethylsiloxy-3-cyanopropylmethylmethoxysiloxy scroll polymer and chrysotile-derived vinyldimethylsiloxy-3-cyanopropylmethylmethoxysiloxy scroll polymer, have been made by a novel pendent group-exchange reaction. Finally, partially platinum-filled scrolls have been prepared.</p> 2008-03-25 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197 http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Chemistry Pc Si CH2 CH3 3NH HOSiPcOSi CH2Cl2
spellingShingle	Chemistry Pc Si CH2 CH3 3NH HOSiPcOSi CH2Cl2 Guo, Ming SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
author	Guo, Ming
author_facet	Guo, Ming
author_sort	Guo, Ming
title	SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_short	SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_full	SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_fullStr	SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_full_unstemmed	SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_sort	synthesis and characterization of silicon phthalocyanines for photodynamic therapy
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2008
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197
work_keys_str_mv	AT guoming synthesisandcharacterizationofsiliconphthalocyaninesforphotodynamictherapy
_version_	1719421509283348480

SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY

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