An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency

An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency

Bibliographic Details
Main Author: Gildea, Thomas R.
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2010
Subjects:
Biomedical Research
Biostatistics
Alpha-1 antitrypsin deficiency
Lung Transplant
FEV1
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1247086953
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case12470869532021-08-03T05:33:15Z An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency Gildea, Thomas R. Biomedical Research Biostatistics Alpha-1 antitrypsin deficiency Lung Transplant FEV1 Alpha-1 antitrypsin deficiency (AATD) allows proteolytic lung damage manifested by decline in FEV1 (forced expiratory volume in first second). Augmentation with AAT may slow FEV1 decline. Infection and rejection after transplantation are associated with higher levels of proteolytic enzymes in AATD. Augmentation is generally not given after transplant. Retrospectively, we compare FEV1% predicted decline of those with AATD (45 [16%]) and AAT-replete chronic obstructive pulmonary disease (COPD) (231 [86%]) stratified by single or double lung transplant. Temporal decomposition was used to plot the trends. Double lung recipients with AATD had a greater FEV1 decline compared AAT-replete COPD. No difference in incident rejection was noted. Multivariable analysis showed higher post-operative FEV1 associated with higher preoperative FEV1, older age, lower Class-I panel reactive antibody, and right lung transplanted. Despite limitations, these observations raise questions regarding decline of lung function in AATD post-transplant, e.g., what role is augmentation after lung transplant in AATD? 2010-01-23 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1247086953 http://rave.ohiolink.edu/etdc/view?acc_num=case1247086953 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomedical Research
Biostatistics
Alpha-1 antitrypsin deficiency
Lung Transplant
FEV1
spellingShingle Biomedical Research
Biostatistics
Alpha-1 antitrypsin deficiency
Lung Transplant
FEV1
Gildea, Thomas R.
An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency
author Gildea, Thomas R.
author_facet Gildea, Thomas R.
author_sort Gildea, Thomas R.
title An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency
title_short An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency
title_full An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency
title_fullStr An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency
title_full_unstemmed An Analysis of Post Lung Transplant FEV1 Change in Alpha-1 Antitrypsin Deficiency
title_sort analysis of post lung transplant fev1 change in alpha-1 antitrypsin deficiency
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=case1247086953
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