Intravascular Optical Coherence Tomography Image Analysis

Bibliographic Details
Main Author:	Wang, Zhao
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2013
Subjects:	Biomedical Engineering Optics Information Technology coronary artery disease optical coherence tomography image analysis image processing atherosclerotic plaques stents
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1364673682

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case13646736822021-08-03T05:21:28Z Intravascular Optical Coherence Tomography Image Analysis Wang, Zhao Biomedical Engineering Optics Information Technology coronary artery disease optical coherence tomography image analysis image processing atherosclerotic plaques stents Coronary artery disease (CAD) is the leading cause of death in the world. Most acute coronary events such as heart attacks and sudden deaths are due to the rupture of atherosclerotic plaques inside the arteries. Intravascular Optical Coherence Tomography (IVOCT), a high resolution (10-20µm) imaging modality that performs cross-sectional imaging of coronary arteries by measuring echoes of backscattered light, is rapidly becoming a promising imaging modality for diagnosis of CAD. Compared to alternative technologies such as intravascular ultrasound (IVUS), IVOCT with better resolution allows characterization of atherosclerotic plaques and evaluation of coronary stenting with unprecendented details. Currently, analysis of OCT images has been typically conducted manually in an extremely time-consuming manner. The aim of this PhD dissertation is to develop advanced image processing algorithms and software to automate the task and thereby reduce the image analysis time drastically.In this dissertation, we developed image analysis algorithms for a variety of IVOCT applications, including: (1) 3-D lumen boundary segmentation, (2) Guide wire artifact segmentation, (3) Automated calibration of IVOCT images, (4) Volumetric quantification of fibrous caps, (5) Automated segmentation of calcified plaques, (6) Automated quantification of macrophages and (7) Automated stent analysis, covering almost all the essential tasks performed in the Cardiovascular Imaging Core Laboratories (Core Lab). The algorithms we have developed have been extensively validated using a large number of data sets, and are robust to be used for real world clinical data analysis. Furthermore, we developed the prototype software OCTivat (intravascular OCT image visualization and analysis toolkit) for IVOCT image visualization and analysis, and it is being used by the interventional cardiologists in the Core Lab at the University Hospitals Case Medical Center. These image analysis methods, as well as OCTivat, can reduce the IVOCT image analysis time from tens of hours down to minutes. This may enable large clinical trial analysis and real-time feedback during clinical procedures, and may potentially improve patient care. 2013-08-19 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1364673682 http://rave.ohiolink.edu/etdc/view?acc_num=case1364673682 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection	NDLTD
language	English
sources	NDLTD
topic	Biomedical Engineering Optics Information Technology coronary artery disease optical coherence tomography image analysis image processing atherosclerotic plaques stents
spellingShingle	Biomedical Engineering Optics Information Technology coronary artery disease optical coherence tomography image analysis image processing atherosclerotic plaques stents Wang, Zhao Intravascular Optical Coherence Tomography Image Analysis
author	Wang, Zhao
author_facet	Wang, Zhao
author_sort	Wang, Zhao
title	Intravascular Optical Coherence Tomography Image Analysis
title_short	Intravascular Optical Coherence Tomography Image Analysis
title_full	Intravascular Optical Coherence Tomography Image Analysis
title_fullStr	Intravascular Optical Coherence Tomography Image Analysis
title_full_unstemmed	Intravascular Optical Coherence Tomography Image Analysis
title_sort	intravascular optical coherence tomography image analysis
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2013
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1364673682
work_keys_str_mv	AT wangzhao intravascularopticalcoherencetomographyimageanalysis
_version_	1719418599287816192

Intravascular Optical Coherence Tomography Image Analysis

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