Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes
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Cleveland State University / OhioLINK
2012
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-csu13739878242021-08-03T06:18:27Z Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes Smith, Kerri M. Chemistry Analytical Chemistry Mass spectrometry is a valuable tool in the analysis of many types ofcompounds. From small molecules to large proteins, mass spectrometrycan help to interrogate samples and give insights to the origins of diseaseas well as calculate an exact concentration. Bioanalytical methoddevelopment is an integral component in the measurement of suchcompounds. To facilitate proper analytical investigation, the process ofmethod development, analysis, and interpretation must be understood.This work describes the basis and procedure for bioanalytical methoddevelopment and its detailed application to preclinical studies of theantineoplastic agent hexamethylene bisacetamide and measurement ofillicit drugs of abuse benzylpiperazine and trifluoromethylphenylpiperazine using liquid chromatography tandem mass spectrometry.Additionally, procedures for analyzing protein-drug interactions and theirimplication in antibiotic resistance are discussed. 2012 English text Cleveland State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824 http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Chemistry Analytical Chemistry |
| spellingShingle |
Chemistry Analytical Chemistry Smith, Kerri M. Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes |
| author |
Smith, Kerri M. |
| author_facet |
Smith, Kerri M. |
| author_sort |
Smith, Kerri M. |
| title |
Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes |
| title_short |
Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes |
| title_full |
Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes |
| title_fullStr |
Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes |
| title_full_unstemmed |
Quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes |
| title_sort |
quantitative and qualitative mass spectrometric analysis of anticancer agents, drugs of abuse and enzyme-inhibitor complexes |
| publisher |
Cleveland State University / OhioLINK |
| publishDate |
2012 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=csu1373987824 |
| work_keys_str_mv |
AT smithkerrim quantitativeandqualitativemassspectrometricanalysisofanticanceragentsdrugsofabuseandenzymeinhibitorcomplexes |
| _version_ |
1719434365495148544 |