The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression

The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression

Bibliographic Details
Main Author: Barnard, David French
Language:English
Published: Kent State University / OhioLINK 2020
Subjects:
Biology
Neurosciences
stress
depression
cytokines
norepinephrine
glucocorticoids
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-kent1586871098824352021-08-03T07:14:07Z The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression Barnard, David French Biology Neurosciences stress depression cytokines norepinephrine glucocorticoids The dysregulation of pro-inflammatory cytokines as a result of stress exposure has become widely implicated in the complex etiology of depression. Patients with depression have been shown to have elevated levels of pro-inflammatory cytokines both in plasma and cerebral spinal fluid. During times of stress pro-inflammatory cytokines are primarily regulated by glucocorticoids and catecholamines that work in opposition to one another to inhibit (glucocorticoid receptor) or stimulate (beta-adrenergic receptor) pro-inflammatory cytokine production. While chronic stress can lead to heightened levels of both glucocorticoids and catecholamines, it is not known how the dysregulation of these systems affect the regulation of pro-inflammatory cytokines. This dissertation focused its work through three aims. Aim 1 explored norepinephrine’s regulation of microglial pro-inflammatory cytokines. Aim 2 examined sex differences in the regulation of brain IL-1 beta by glucocorticoids and catecholamines following chronic stress. Finally, aim 3 sought to uncover glucocorticoids effect on norepinephrine turnover. Together, these aims help to better understand how chronic stress alters the regulation of brain pro-inflammatory cytokines with implications for depression. 2020-04-15 English text Kent State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435 http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biology
Neurosciences
stress
depression
cytokines
norepinephrine
glucocorticoids
spellingShingle Biology
Neurosciences
stress
depression
cytokines
norepinephrine
glucocorticoids
Barnard, David French
The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression
author Barnard, David French
author_facet Barnard, David French
author_sort Barnard, David French
title The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression
title_short The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression
title_full The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression
title_fullStr The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression
title_full_unstemmed The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression
title_sort regulation of brain pro-inflammatory cytokines: implications for stress and depression
publisher Kent State University / OhioLINK
publishDate 2020
url http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435
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