Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents

Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents

Bibliographic Details
Main Author: Zheng, Zilong
Language:English
Published: Ohio University / OhioLINK 2016
Subjects:
Chemistry
Oxazolidinones
aziridine
anti-influenza
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ohiou14707393692021-08-03T06:38:16Z Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents Zheng, Zilong Chemistry Oxazolidinones aziridine anti-influenza Oxazolidinones Derivatives are useful compounds in both synthetic chemistry and biochemistry. The addition reaction of fused ring aziridine and halides was developed, which provide a new way of preparing of oxazolidinone derivatives. Here the halides could be both highly reactive haloformates and less reactive haloacetates, benzyl halides and allylic halides. The addition reaction of fused ring aziridine and iodoacetate also provided a way to the synthesis of bicyclic compound, which could be opened by amine and amino acid. The method proved to be a useful method in the synthesis of peptidomimetics with oxazolidinone structure.A library of A3 analogue were prepared as anti-influenza agents. Compared to A3 compound, the oxadiazole unit was replaced with different substitutions, such as hydrazide and triazole. The indole unit was replaced with benzyl group with different substitutions. 2016-09-30 English text Ohio University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369 http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Chemistry
Oxazolidinones
aziridine
anti-influenza
spellingShingle Chemistry
Oxazolidinones
aziridine
anti-influenza
Zheng, Zilong
Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
author Zheng, Zilong
author_facet Zheng, Zilong
author_sort Zheng, Zilong
title Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
title_short Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
title_full Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
title_fullStr Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
title_full_unstemmed Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
title_sort synthesis of oxazolidinone derivatives and anti-influenza agents
publisher Ohio University / OhioLINK
publishDate 2016
url http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369
work_keys_str_mv AT zhengzilong synthesisofoxazolidinonederivativesandantiinfluenzaagents
_version_ 1719440611394715648

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